Compounds 1 a ∼ f were synthesized from 4, 5-dichloropyridazinone 4 under two different conditions (NaH/DMF or NaOH/acetone). The nucleophilic substitution of 4-chloro-5-(β-bromo-ethoxy)-pyridazinone 3 with aromatic aldehyde (ketone) oximes afforded exclusively the product 2 in the condition of PTC. However, it led to a mixture of 1 and 2 reacting with alphatic ketone oximes. The regioselectivity of the reaction affacted by nucleophiles and reaction conditions was also discussed.
|Original language||English (US)|
|Number of pages||1|
|Journal||Chinese Journal of Organic Chemistry|
|Publication status||Published - 1997|
- Oxime ether
ASJC Scopus subject areas
- Organic Chemistry