Abstract
Compounds 1 a ∼ f were synthesized from 4, 5-dichloropyridazinone 4 under two different conditions (NaH/DMF or NaOH/acetone). The nucleophilic substitution of 4-chloro-5-(β-bromo-ethoxy)-pyridazinone 3 with aromatic aldehyde (ketone) oximes afforded exclusively the product 2 in the condition of PTC. However, it led to a mixture of 1 and 2 reacting with alphatic ketone oximes. The regioselectivity of the reaction affacted by nucleophiles and reaction conditions was also discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 241 |
| Number of pages | 1 |
| Journal | Chinese Journal of Organic Chemistry |
| Volume | 17 |
| Issue number | 3 |
| State | Published - 1997 |
| Externally published | Yes |
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Keywords
- Oxime ether
- Pyridazinone
- Regioselectivity
ASJC Scopus subject areas
- Organic Chemistry
Cite this
Synthesis of the oxime ethers containing pyridazinones. / Liu, Tian Lin; Yu, Aiming; Wang, Li Kun.
In: Chinese Journal of Organic Chemistry, Vol. 17, No. 3, 1997, p. 241.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis of the oxime ethers containing pyridazinones
AU - Liu, Tian Lin
AU - Yu, Aiming
AU - Wang, Li Kun
PY - 1997
Y1 - 1997
N2 - Compounds 1 a ∼ f were synthesized from 4, 5-dichloropyridazinone 4 under two different conditions (NaH/DMF or NaOH/acetone). The nucleophilic substitution of 4-chloro-5-(β-bromo-ethoxy)-pyridazinone 3 with aromatic aldehyde (ketone) oximes afforded exclusively the product 2 in the condition of PTC. However, it led to a mixture of 1 and 2 reacting with alphatic ketone oximes. The regioselectivity of the reaction affacted by nucleophiles and reaction conditions was also discussed.
AB - Compounds 1 a ∼ f were synthesized from 4, 5-dichloropyridazinone 4 under two different conditions (NaH/DMF or NaOH/acetone). The nucleophilic substitution of 4-chloro-5-(β-bromo-ethoxy)-pyridazinone 3 with aromatic aldehyde (ketone) oximes afforded exclusively the product 2 in the condition of PTC. However, it led to a mixture of 1 and 2 reacting with alphatic ketone oximes. The regioselectivity of the reaction affacted by nucleophiles and reaction conditions was also discussed.
KW - Oxime ether
KW - Pyridazinone
KW - Regioselectivity
UR - http://www.scopus.com/inward/record.url?scp=0347799789&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0347799789&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0347799789
VL - 17
SP - 241
JO - Chinese Journal of Organic Chemistry
JF - Chinese Journal of Organic Chemistry
SN - 0253-2786
IS - 3
ER -