Synthesis of the oxime ethers containing pyridazinones

Tian Lin Liu, Aiming Yu, Li Kun Wang

Research output: Contribution to journalArticlepeer-review


Compounds 1 a ∼ f were synthesized from 4, 5-dichloropyridazinone 4 under two different conditions (NaH/DMF or NaOH/acetone). The nucleophilic substitution of 4-chloro-5-(β-bromo-ethoxy)-pyridazinone 3 with aromatic aldehyde (ketone) oximes afforded exclusively the product 2 in the condition of PTC. However, it led to a mixture of 1 and 2 reacting with alphatic ketone oximes. The regioselectivity of the reaction affacted by nucleophiles and reaction conditions was also discussed.

Original languageEnglish (US)
Pages (from-to)241
Number of pages1
JournalChinese Journal of Organic Chemistry
Issue number3
StatePublished - 1997
Externally publishedYes


  • Oxime ether
  • Pyridazinone
  • Regioselectivity

ASJC Scopus subject areas

  • Organic Chemistry


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