Abstract
Compounds 1 a ∼ f were synthesized from 4, 5-dichloropyridazinone 4 under two different conditions (NaH/DMF or NaOH/acetone). The nucleophilic substitution of 4-chloro-5-(β-bromo-ethoxy)-pyridazinone 3 with aromatic aldehyde (ketone) oximes afforded exclusively the product 2 in the condition of PTC. However, it led to a mixture of 1 and 2 reacting with alphatic ketone oximes. The regioselectivity of the reaction affacted by nucleophiles and reaction conditions was also discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 241 |
| Number of pages | 1 |
| Journal | Chinese Journal of Organic Chemistry |
| Volume | 17 |
| Issue number | 3 |
| Publication status | Published - 1997 |
| Externally published | Yes |
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Keywords
- Oxime ether
- Pyridazinone
- Regioselectivity
ASJC Scopus subject areas
- Organic Chemistry
Cite this
Liu, T. L., Yu, A., & Wang, L. K. (1997). Synthesis of the oxime ethers containing pyridazinones. Chinese Journal of Organic Chemistry, 17(3), 241.