Synthesis of the oxime ethers containing pyridazinones

Tian Lin Liu; Aiming Yu; Li Kun Wang

Synthesis of the oxime ethers containing pyridazinones

Tian Lin Liu, Aiming Yu, Li Kun Wang

Research output: Contribution to journal › Article › peer-review

Abstract

Compounds 1 a ∼ f were synthesized from 4, 5-dichloropyridazinone 4 under two different conditions (NaH/DMF or NaOH/acetone). The nucleophilic substitution of 4-chloro-5-(β-bromo-ethoxy)-pyridazinone 3 with aromatic aldehyde (ketone) oximes afforded exclusively the product 2 in the condition of PTC. However, it led to a mixture of 1 and 2 reacting with alphatic ketone oximes. The regioselectivity of the reaction affacted by nucleophiles and reaction conditions was also discussed.

Original language	English (US)
Pages (from-to)	241
Number of pages	1
Journal	Chinese Journal of Organic Chemistry
Volume	17
Issue number	3
State	Published - 1997
Externally published	Yes

Keywords

Oxime ether
Pyridazinone
Regioselectivity

ASJC Scopus subject areas

Organic Chemistry

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title = "Synthesis of the oxime ethers containing pyridazinones",

abstract = "Compounds 1 a ∼ f were synthesized from 4, 5-dichloropyridazinone 4 under two different conditions (NaH/DMF or NaOH/acetone). The nucleophilic substitution of 4-chloro-5-(β-bromo-ethoxy)-pyridazinone 3 with aromatic aldehyde (ketone) oximes afforded exclusively the product 2 in the condition of PTC. However, it led to a mixture of 1 and 2 reacting with alphatic ketone oximes. The regioselectivity of the reaction affacted by nucleophiles and reaction conditions was also discussed.",

keywords = "Oxime ether, Pyridazinone, Regioselectivity",

author = "Liu, {Tian Lin} and Aiming Yu and Wang, {Li Kun}",

year = "1997",

language = "English (US)",

volume = "17",

pages = "241",

journal = "Chinese Journal of Organic Chemistry",

issn = "0253-2786",

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number = "3",

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TY - JOUR

T1 - Synthesis of the oxime ethers containing pyridazinones

AU - Liu, Tian Lin

AU - Yu, Aiming

AU - Wang, Li Kun

PY - 1997

Y1 - 1997

N2 - Compounds 1 a ∼ f were synthesized from 4, 5-dichloropyridazinone 4 under two different conditions (NaH/DMF or NaOH/acetone). The nucleophilic substitution of 4-chloro-5-(β-bromo-ethoxy)-pyridazinone 3 with aromatic aldehyde (ketone) oximes afforded exclusively the product 2 in the condition of PTC. However, it led to a mixture of 1 and 2 reacting with alphatic ketone oximes. The regioselectivity of the reaction affacted by nucleophiles and reaction conditions was also discussed.

AB - Compounds 1 a ∼ f were synthesized from 4, 5-dichloropyridazinone 4 under two different conditions (NaH/DMF or NaOH/acetone). The nucleophilic substitution of 4-chloro-5-(β-bromo-ethoxy)-pyridazinone 3 with aromatic aldehyde (ketone) oximes afforded exclusively the product 2 in the condition of PTC. However, it led to a mixture of 1 and 2 reacting with alphatic ketone oximes. The regioselectivity of the reaction affacted by nucleophiles and reaction conditions was also discussed.

KW - Oxime ether

KW - Pyridazinone

KW - Regioselectivity

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VL - 17

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JO - Chinese Journal of Organic Chemistry

JF - Chinese Journal of Organic Chemistry

SN - 0253-2786

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