Synthesis of the insecticide prothrin and its analogues from biomass-derived 5-(chloromethyl)furfural

Fei Chang, Saikat Dutta, James J. Becnel, Alden S. Estep, Mark Mascal

Research output: Contribution to journalArticle

27 Scopus citations


Prothrin, a synthetic pyrethroid insecticide, was synthesized from the biomass-derived platform chemical 5-(chloromethyl)furfural in six steps and overall 65% yield. Two structural analogues of prothrin were also prepared following the same synthetic approach. Preliminary testing of these furan-based pyrethroids against the yellow fever mosquito Aedes aegypti indicates promising insecticidal activities.

Original languageEnglish (US)
Pages (from-to)476-480
Number of pages5
JournalJournal of Agricultural and Food Chemistry
Issue number2
StatePublished - Jan 15 2014



  • 5-(chloromethyl)furfural
  • biomass
  • furans
  • pyrethroids
  • synthesis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

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