Synthesis of the insecticide prothrin and its analogues from biomass-derived 5-(chloromethyl)furfural

Fei Chang, Saikat Dutta, James J. Becnel, Alden S. Estep, Mark Mascal

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Prothrin, a synthetic pyrethroid insecticide, was synthesized from the biomass-derived platform chemical 5-(chloromethyl)furfural in six steps and overall 65% yield. Two structural analogues of prothrin were also prepared following the same synthetic approach. Preliminary testing of these furan-based pyrethroids against the yellow fever mosquito Aedes aegypti indicates promising insecticidal activities.

Original languageEnglish (US)
Pages (from-to)476-480
Number of pages5
JournalJournal of Agricultural and Food Chemistry
Volume62
Issue number2
DOIs
StatePublished - Jan 15 2014

Fingerprint

Pyrethrins
furfural
Insecticides
Aedes aegypti
Biomass
insecticides
Yellow Fever
pyrethroid insecticides
synthesis
Aedes
furans
biomass
pyrethrins
Culicidae
Testing
testing
5-(chloromethyl)furfural
furan

Keywords

  • 5-(chloromethyl)furfural
  • biomass
  • furans
  • pyrethroids
  • synthesis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

Cite this

Synthesis of the insecticide prothrin and its analogues from biomass-derived 5-(chloromethyl)furfural. / Chang, Fei; Dutta, Saikat; Becnel, James J.; Estep, Alden S.; Mascal, Mark.

In: Journal of Agricultural and Food Chemistry, Vol. 62, No. 2, 15.01.2014, p. 476-480.

Research output: Contribution to journalArticle

Chang, Fei ; Dutta, Saikat ; Becnel, James J. ; Estep, Alden S. ; Mascal, Mark. / Synthesis of the insecticide prothrin and its analogues from biomass-derived 5-(chloromethyl)furfural. In: Journal of Agricultural and Food Chemistry. 2014 ; Vol. 62, No. 2. pp. 476-480.
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