Synthesis of the G-C DNA base hybrid with a functional tail

Mark Mascal, Steven C. Farmer, James R. Arnall-Culliford

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14 Scopus citations

Abstract

Molecules which possess the hydrogen bonding codes of both guanine and cytosine ("G-C DNA base hybrids") are known to organize in a hexagonal array both in solution and the solid state. Including an easily derivatizable functional group in the molecule allows the co-organization of virtually any species in the hexagonal periphery. Simple 5- and 6-step procedures are described for the synthesis of DNA base hybrids with tail groups which are terminated by electrophilic (primary bromide) and nucleophilic (primary alcohol) functions, respectively.

Original languageEnglish (US)
Pages (from-to)8146-8150
Number of pages5
JournalJournal of Organic Chemistry
Volume71
Issue number21
DOIs
Publication statusPublished - Oct 13 2006

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ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Mascal, M., Farmer, S. C., & Arnall-Culliford, J. R. (2006). Synthesis of the G-C DNA base hybrid with a functional tail. Journal of Organic Chemistry, 71(21), 8146-8150. https://doi.org/10.1021/jo061304s