Synthesis of the G-C DNA base hybrid with a functional tail

Mark Mascal, Steven C. Farmer, James R. Arnall-Culliford

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Molecules which possess the hydrogen bonding codes of both guanine and cytosine ("G-C DNA base hybrids") are known to organize in a hexagonal array both in solution and the solid state. Including an easily derivatizable functional group in the molecule allows the co-organization of virtually any species in the hexagonal periphery. Simple 5- and 6-step procedures are described for the synthesis of DNA base hybrids with tail groups which are terminated by electrophilic (primary bromide) and nucleophilic (primary alcohol) functions, respectively.

Original languageEnglish (US)
Pages (from-to)8146-8150
Number of pages5
JournalJournal of Organic Chemistry
Volume71
Issue number21
DOIs
StatePublished - Oct 13 2006

ASJC Scopus subject areas

  • Organic Chemistry

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