Synthesis of 13C3-hydroxyacetone

Christopher W. Dicus, Kevin Burnham, M. Judith Charles, Michael H. Nantz

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


13C3-Hydroxyacetone is prepared in three steps from 13C2-2-bromoacetic acid. Bromide displacement by sodium p-methoxybenzyl alkoxide followed by treatment of the carboxylic acid with 13C-methyl lithium furnishes PMB-protected hydroxyacetone. Deprotection using DDQ delivers the title compound.

Original languageEnglish (US)
Pages (from-to)793-798
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number9
StatePublished - Aug 2003


  • Acetol
  • Acyloin
  • Carbon-13
  • Methyl ketone

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Organic Chemistry
  • Clinical Biochemistry
  • Molecular Medicine
  • Pharmacology


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