Synthesis of 13C3-hydroxyacetone

Christopher W. Dicus, Kevin Burnham, M. Judith Charles, Michael H. Nantz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

13C3-Hydroxyacetone is prepared in three steps from 13C2-2-bromoacetic acid. Bromide displacement by sodium p-methoxybenzyl alkoxide followed by treatment of the carboxylic acid with 13C-methyl lithium furnishes PMB-protected hydroxyacetone. Deprotection using DDQ delivers the title compound.

Original languageEnglish (US)
Pages (from-to)793-798
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume46
Issue number9
DOIs
StatePublished - Aug 2003

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Carboxylic Acids
Bromides
Lithium
Sodium
acetol
bromoacetate
sodium bromide

Keywords

  • Acetol
  • Acyloin
  • Carbon-13
  • Methyl ketone

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Organic Chemistry
  • Clinical Biochemistry
  • Molecular Medicine
  • Pharmacology

Cite this

Synthesis of 13C3-hydroxyacetone. / Dicus, Christopher W.; Burnham, Kevin; Charles, M. Judith; Nantz, Michael H.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 46, No. 9, 08.2003, p. 793-798.

Research output: Contribution to journalArticle

Dicus, Christopher W. ; Burnham, Kevin ; Charles, M. Judith ; Nantz, Michael H. / Synthesis of 13C3-hydroxyacetone. In: Journal of Labelled Compounds and Radiopharmaceuticals. 2003 ; Vol. 46, No. 9. pp. 793-798.
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