Synthesis of sulfone-based nucleotide isosteres: Identification of CMP-sialic acid synthetase inhibitors

Jessica H. Wong, Urvashi Sahni, Yanhong Li, Xi Chen, Jacquelyn Gervay-Hague

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A modular replacement approach to the synthesis of sulfo-nucleotide analogs prepared from condensation of nucleoside aldehydes with bis phosphonate Horner-Wadsworth-Emmons reagents is disclosed. These analogs were shown to be inhibitors of Neisseria meningitidis CSS (NmCSS), which is a key enzyme in the biosynthesis of the capsular polysaccharides required for bacterial infection.

Original languageEnglish (US)
Pages (from-to)27-29
Number of pages3
JournalOrganic and Biomolecular Chemistry
Volume7
Issue number1
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

Fingerprint Dive into the research topics of 'Synthesis of sulfone-based nucleotide isosteres: Identification of CMP-sialic acid synthetase inhibitors'. Together they form a unique fingerprint.

  • Cite this