Abstract
Routes to structurally unique spiro-fused pyrazolidoylisoxazolines are reported. These methods start with monosubstituted hydrazines or hydrazides and utilize the nitrile oxide 1,3-dipolar cycloaddition reaction to generate the targeted spiro-fused bis-heterocycles. Molecular shape space diversity analyses were performed on these pyrazolidoylisoxazolines showing that manipulation of the appended R groups significantly changes the molecular shape.
Original language | English (US) |
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Pages (from-to) | 5803-5812 |
Number of pages | 10 |
Journal | Journal of Organic Chemistry |
Volume | 76 |
Issue number | 14 |
DOIs | |
State | Published - Jul 15 2011 |
ASJC Scopus subject areas
- Organic Chemistry