Synthesis of spiro-fused pyrazolidoylisoxazolines

Kathryn G. Guggenheim; Jeffrey D. Butler; Phillip P. Painter; Beth A. Lorsbach; Dean J. Tantillo; Mark J. Kurth

doi:10.1021/jo200924y

Synthesis of spiro-fused pyrazolidoylisoxazolines

Kathryn G. Guggenheim, Jeffrey D. Butler, Phillip P. Painter, Beth A. Lorsbach, Dean J. Tantillo, Mark J. Kurth

Chemistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Routes to structurally unique spiro-fused pyrazolidoylisoxazolines are reported. These methods start with monosubstituted hydrazines or hydrazides and utilize the nitrile oxide 1,3-dipolar cycloaddition reaction to generate the targeted spiro-fused bis-heterocycles. Molecular shape space diversity analyses were performed on these pyrazolidoylisoxazolines showing that manipulation of the appended R groups significantly changes the molecular shape.

Original language	English (US)
Pages (from-to)	5803-5812
Number of pages	10
Journal	Journal of Organic Chemistry
Volume	76
Issue number	14
DOIs	https://doi.org/10.1021/jo200924y
State	Published - Jul 15 2011

ASJC Scopus subject areas

Organic Chemistry

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abstract = "Routes to structurally unique spiro-fused pyrazolidoylisoxazolines are reported. These methods start with monosubstituted hydrazines or hydrazides and utilize the nitrile oxide 1,3-dipolar cycloaddition reaction to generate the targeted spiro-fused bis-heterocycles. Molecular shape space diversity analyses were performed on these pyrazolidoylisoxazolines showing that manipulation of the appended R groups significantly changes the molecular shape.",

author = "Guggenheim, {Kathryn G.} and Butler, {Jeffrey D.} and Painter, {Phillip P.} and Lorsbach, {Beth A.} and Tantillo, {Dean J.} and Kurth, {Mark J.}",

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AU - Guggenheim, Kathryn G.

AU - Butler, Jeffrey D.

AU - Painter, Phillip P.

AU - Lorsbach, Beth A.

AU - Tantillo, Dean J.

AU - Kurth, Mark J.

PY - 2011/7/15

Y1 - 2011/7/15

N2 - Routes to structurally unique spiro-fused pyrazolidoylisoxazolines are reported. These methods start with monosubstituted hydrazines or hydrazides and utilize the nitrile oxide 1,3-dipolar cycloaddition reaction to generate the targeted spiro-fused bis-heterocycles. Molecular shape space diversity analyses were performed on these pyrazolidoylisoxazolines showing that manipulation of the appended R groups significantly changes the molecular shape.

AB - Routes to structurally unique spiro-fused pyrazolidoylisoxazolines are reported. These methods start with monosubstituted hydrazines or hydrazides and utilize the nitrile oxide 1,3-dipolar cycloaddition reaction to generate the targeted spiro-fused bis-heterocycles. Molecular shape space diversity analyses were performed on these pyrazolidoylisoxazolines showing that manipulation of the appended R groups significantly changes the molecular shape.

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Synthesis of spiro-fused pyrazolidoylisoxazolines

Abstract

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