Synthesis of long T 1 silicon nanoparticles for hyperpolarized 29Si magnetic resonance imaging

Tonya M. Atkins, Maja C. Cassidy, Menyoung Lee, Shreyashi Ganguly, Charles M. Marcus, Susan M. Kauzlarich

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

We describe the synthesis, materials characterization, and dynamic nuclear polarization (DNP) of amorphous and crystalline silicon nanoparticles for use as hyperpolarized magnetic resonance imaging (MRI) agents. The particles were synthesized by means of a metathesis reaction between sodium silicide (Na 4Si4) and silicon tetrachloride (SiCl4) and were surface functionalized with a variety of passivating ligands. The synthesis scheme results in particles of diameter ∼10 nm with long size-adjusted 29Si spin-lattice relaxation (T1) times (>600 s), which are retained after hyperpolarization by low-temperature DNP.

Original languageEnglish (US)
Pages (from-to)1609-1617
Number of pages9
JournalACS Nano
Volume7
Issue number2
DOIs
StatePublished - Feb 26 2013

Fingerprint

Silicon
Magnetic resonance
magnetic resonance
silicon tetrachloride
Polarization
Nanoparticles
Imaging techniques
nanoparticles
Spin-lattice relaxation
metathesis
silicon
polarization
synthesis
spin-lattice relaxation
Relaxation time
amorphous silicon
relaxation time
Sodium
Ligands
sodium

Keywords

  • dynamic nuclear polarization
  • hyperpolarization
  • magnetic resonance imaging
  • nanomedicine
  • nanoparticle
  • silicon

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Physics and Astronomy(all)

Cite this

Atkins, T. M., Cassidy, M. C., Lee, M., Ganguly, S., Marcus, C. M., & Kauzlarich, S. M. (2013). Synthesis of long T 1 silicon nanoparticles for hyperpolarized 29Si magnetic resonance imaging. ACS Nano, 7(2), 1609-1617. https://doi.org/10.1021/nn305462y

Synthesis of long T 1 silicon nanoparticles for hyperpolarized 29Si magnetic resonance imaging. / Atkins, Tonya M.; Cassidy, Maja C.; Lee, Menyoung; Ganguly, Shreyashi; Marcus, Charles M.; Kauzlarich, Susan M.

In: ACS Nano, Vol. 7, No. 2, 26.02.2013, p. 1609-1617.

Research output: Contribution to journalArticle

Atkins, TM, Cassidy, MC, Lee, M, Ganguly, S, Marcus, CM & Kauzlarich, SM 2013, 'Synthesis of long T 1 silicon nanoparticles for hyperpolarized 29Si magnetic resonance imaging', ACS Nano, vol. 7, no. 2, pp. 1609-1617. https://doi.org/10.1021/nn305462y
Atkins TM, Cassidy MC, Lee M, Ganguly S, Marcus CM, Kauzlarich SM. Synthesis of long T 1 silicon nanoparticles for hyperpolarized 29Si magnetic resonance imaging. ACS Nano. 2013 Feb 26;7(2):1609-1617. https://doi.org/10.1021/nn305462y
Atkins, Tonya M. ; Cassidy, Maja C. ; Lee, Menyoung ; Ganguly, Shreyashi ; Marcus, Charles M. ; Kauzlarich, Susan M. / Synthesis of long T 1 silicon nanoparticles for hyperpolarized 29Si magnetic resonance imaging. In: ACS Nano. 2013 ; Vol. 7, No. 2. pp. 1609-1617.
@article{416dbd63cbbb4db58374655a113c4fdb,
title = "Synthesis of long T 1 silicon nanoparticles for hyperpolarized 29Si magnetic resonance imaging",
abstract = "We describe the synthesis, materials characterization, and dynamic nuclear polarization (DNP) of amorphous and crystalline silicon nanoparticles for use as hyperpolarized magnetic resonance imaging (MRI) agents. The particles were synthesized by means of a metathesis reaction between sodium silicide (Na 4Si4) and silicon tetrachloride (SiCl4) and were surface functionalized with a variety of passivating ligands. The synthesis scheme results in particles of diameter ∼10 nm with long size-adjusted 29Si spin-lattice relaxation (T1) times (>600 s), which are retained after hyperpolarization by low-temperature DNP.",
keywords = "dynamic nuclear polarization, hyperpolarization, magnetic resonance imaging, nanomedicine, nanoparticle, silicon",
author = "Atkins, {Tonya M.} and Cassidy, {Maja C.} and Menyoung Lee and Shreyashi Ganguly and Marcus, {Charles M.} and Kauzlarich, {Susan M.}",
year = "2013",
month = "2",
day = "26",
doi = "10.1021/nn305462y",
language = "English (US)",
volume = "7",
pages = "1609--1617",
journal = "ACS Nano",
issn = "1936-0851",
publisher = "American Chemical Society",
number = "2",

}

TY - JOUR

T1 - Synthesis of long T 1 silicon nanoparticles for hyperpolarized 29Si magnetic resonance imaging

AU - Atkins, Tonya M.

AU - Cassidy, Maja C.

AU - Lee, Menyoung

AU - Ganguly, Shreyashi

AU - Marcus, Charles M.

AU - Kauzlarich, Susan M.

PY - 2013/2/26

Y1 - 2013/2/26

N2 - We describe the synthesis, materials characterization, and dynamic nuclear polarization (DNP) of amorphous and crystalline silicon nanoparticles for use as hyperpolarized magnetic resonance imaging (MRI) agents. The particles were synthesized by means of a metathesis reaction between sodium silicide (Na 4Si4) and silicon tetrachloride (SiCl4) and were surface functionalized with a variety of passivating ligands. The synthesis scheme results in particles of diameter ∼10 nm with long size-adjusted 29Si spin-lattice relaxation (T1) times (>600 s), which are retained after hyperpolarization by low-temperature DNP.

AB - We describe the synthesis, materials characterization, and dynamic nuclear polarization (DNP) of amorphous and crystalline silicon nanoparticles for use as hyperpolarized magnetic resonance imaging (MRI) agents. The particles were synthesized by means of a metathesis reaction between sodium silicide (Na 4Si4) and silicon tetrachloride (SiCl4) and were surface functionalized with a variety of passivating ligands. The synthesis scheme results in particles of diameter ∼10 nm with long size-adjusted 29Si spin-lattice relaxation (T1) times (>600 s), which are retained after hyperpolarization by low-temperature DNP.

KW - dynamic nuclear polarization

KW - hyperpolarization

KW - magnetic resonance imaging

KW - nanomedicine

KW - nanoparticle

KW - silicon

UR - http://www.scopus.com/inward/record.url?scp=84874433268&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874433268&partnerID=8YFLogxK

U2 - 10.1021/nn305462y

DO - 10.1021/nn305462y

M3 - Article

C2 - 23350651

AN - SCOPUS:84874433268

VL - 7

SP - 1609

EP - 1617

JO - ACS Nano

JF - ACS Nano

SN - 1936-0851

IS - 2

ER -