Synthesis of long T 1 silicon nanoparticles for hyperpolarized 29Si magnetic resonance imaging

Tonya M. Atkins, Maja C. Cassidy, Menyoung Lee, Shreyashi Ganguly, Charles M. Marcus, Susan M. Kauzlarich

Research output: Contribution to journalArticle

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Abstract

We describe the synthesis, materials characterization, and dynamic nuclear polarization (DNP) of amorphous and crystalline silicon nanoparticles for use as hyperpolarized magnetic resonance imaging (MRI) agents. The particles were synthesized by means of a metathesis reaction between sodium silicide (Na 4Si4) and silicon tetrachloride (SiCl4) and were surface functionalized with a variety of passivating ligands. The synthesis scheme results in particles of diameter ∼10 nm with long size-adjusted 29Si spin-lattice relaxation (T1) times (>600 s), which are retained after hyperpolarization by low-temperature DNP.

Original languageEnglish (US)
Pages (from-to)1609-1617
Number of pages9
JournalACS Nano
Volume7
Issue number2
DOIs
StatePublished - Feb 26 2013

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Keywords

  • dynamic nuclear polarization
  • hyperpolarization
  • magnetic resonance imaging
  • nanomedicine
  • nanoparticle
  • silicon

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Physics and Astronomy(all)

Cite this

Atkins, T. M., Cassidy, M. C., Lee, M., Ganguly, S., Marcus, C. M., & Kauzlarich, S. M. (2013). Synthesis of long T 1 silicon nanoparticles for hyperpolarized 29Si magnetic resonance imaging. ACS Nano, 7(2), 1609-1617. https://doi.org/10.1021/nn305462y