Abstract
We describe a general method for elaboration of the ethyl sidechain of tamoxifen and its primary 4-hydroxy metabolite. Novel lipidic tamoxifen and a functionalized B-ring analog were synthesized from a common stilbene oxide intermediate for potential liposomal applications including estrogen receptor targeting. (C) 2000 Elsevier Science Ltd.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3295-3298 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 41 |
| Issue number | 18 |
| DOIs | |
| State | Published - Apr 29 2000 |
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ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
Cite this
Synthesis of lipidic tamoxifen. / Lashley, Matthew R.; Nantz, Michael H.
In: Tetrahedron Letters, Vol. 41, No. 18, 29.04.2000, p. 3295-3298.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis of lipidic tamoxifen
AU - Lashley, Matthew R.
AU - Nantz, Michael H.
PY - 2000/4/29
Y1 - 2000/4/29
N2 - We describe a general method for elaboration of the ethyl sidechain of tamoxifen and its primary 4-hydroxy metabolite. Novel lipidic tamoxifen and a functionalized B-ring analog were synthesized from a common stilbene oxide intermediate for potential liposomal applications including estrogen receptor targeting. (C) 2000 Elsevier Science Ltd.
AB - We describe a general method for elaboration of the ethyl sidechain of tamoxifen and its primary 4-hydroxy metabolite. Novel lipidic tamoxifen and a functionalized B-ring analog were synthesized from a common stilbene oxide intermediate for potential liposomal applications including estrogen receptor targeting. (C) 2000 Elsevier Science Ltd.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034728940&partnerID=8YFLogxK
U2 - 10.1016/S0040-4039(00)00421-4
DO - 10.1016/S0040-4039(00)00421-4
M3 - Article
VL - 41
SP - 3295
EP - 3298
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 18
ER -