Abstract
We describe a general method for elaboration of the ethyl sidechain of tamoxifen and its primary 4-hydroxy metabolite. Novel lipidic tamoxifen and a functionalized B-ring analog were synthesized from a common stilbene oxide intermediate for potential liposomal applications including estrogen receptor targeting. (C) 2000 Elsevier Science Ltd.
Original language | English (US) |
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Pages (from-to) | 3295-3298 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 41 |
Issue number | 18 |
DOIs | |
State | Published - Apr 29 2000 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery