Synthesis of lipidic tamoxifen

Matthew R. Lashley, Michael H. Nantz

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We describe a general method for elaboration of the ethyl sidechain of tamoxifen and its primary 4-hydroxy metabolite. Novel lipidic tamoxifen and a functionalized B-ring analog were synthesized from a common stilbene oxide intermediate for potential liposomal applications including estrogen receptor targeting. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)3295-3298
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number18
DOIs
StatePublished - Apr 29 2000

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Tamoxifen
Metabolites
Estrogen Receptors
stilbene oxide

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis of lipidic tamoxifen. / Lashley, Matthew R.; Nantz, Michael H.

In: Tetrahedron Letters, Vol. 41, No. 18, 29.04.2000, p. 3295-3298.

Research output: Contribution to journalArticle

Lashley, MR & Nantz, MH 2000, 'Synthesis of lipidic tamoxifen', Tetrahedron Letters, vol. 41, no. 18, pp. 3295-3298. https://doi.org/10.1016/S0040-4039(00)00421-4
Lashley, Matthew R. ; Nantz, Michael H. / Synthesis of lipidic tamoxifen. In: Tetrahedron Letters. 2000 ; Vol. 41, No. 18. pp. 3295-3298.
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