Synthesis of lipidic tamoxifen

Matthew R. Lashley, Michael H. Nantz

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We describe a general method for elaboration of the ethyl sidechain of tamoxifen and its primary 4-hydroxy metabolite. Novel lipidic tamoxifen and a functionalized B-ring analog were synthesized from a common stilbene oxide intermediate for potential liposomal applications including estrogen receptor targeting. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)3295-3298
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number18
DOIs
StatePublished - Apr 29 2000

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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