Synthesis of lipidic tamoxifen

Matthew R. Lashley; Michael H. Nantz

doi:10.1016/S0040-4039(00)00421-4

Synthesis of lipidic tamoxifen

Matthew R. Lashley, Michael H. Nantz

Chemistry

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

We describe a general method for elaboration of the ethyl sidechain of tamoxifen and its primary 4-hydroxy metabolite. Novel lipidic tamoxifen and a functionalized B-ring analog were synthesized from a common stilbene oxide intermediate for potential liposomal applications including estrogen receptor targeting. (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	3295-3298
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	18
DOIs	https://doi.org/10.1016/S0040-4039(00)00421-4
State	Published - Apr 29 2000

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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abstract = "We describe a general method for elaboration of the ethyl sidechain of tamoxifen and its primary 4-hydroxy metabolite. Novel lipidic tamoxifen and a functionalized B-ring analog were synthesized from a common stilbene oxide intermediate for potential liposomal applications including estrogen receptor targeting. (C) 2000 Elsevier Science Ltd.",

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AB - We describe a general method for elaboration of the ethyl sidechain of tamoxifen and its primary 4-hydroxy metabolite. Novel lipidic tamoxifen and a functionalized B-ring analog were synthesized from a common stilbene oxide intermediate for potential liposomal applications including estrogen receptor targeting. (C) 2000 Elsevier Science Ltd.

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JO - Tetrahedron Letters

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