Synthesis of hydrophilic and flexible linkers for peptide derivatization in solid phase

Aimin Song, Xiaobing Wang, Jinhua Zhang, Jan Mařík, Carlito B Lebrilla, Kit Lam

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Four N-Fmoc protected polyoxyethylene-based amino acid type linkers were designed and synthesized for peptide derivatization in solid phase. Three of them were obtained in a crystalline form. The crystallized linkers can be stored at 4°C for 2 years without significant decomposition. Protocols for biotinylation and fluorescent labeling of peptides in solid phase were developed. The linkers also provide good ionization ability for single-bead mass spectrometry analysis of peptides.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number1
DOIs
StatePublished - Jan 5 2004

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Synthesis of hydrophilic and flexible linkers for peptide derivatization in solid phase'. Together they form a unique fingerprint.

  • Cite this