Synthesis of hexahydro-1H-pyrrolo[1,2-c]imidazole derivatives by sequential azomethine ylide cycloaddition and urea cyclization reactions

Samir Najdi, Kyung Ho Park, Marilyn M. Olmstead, Mark J. Kurth

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

An efficient, diastereoselective route to 2,5,6,7-tetrasubstituted 1H- pyrrolo[1,2-c]imidazoles has been developed using azomethine ylide cycloaddition and urea cyclization reactions. Relative stereochemical assignments at the four contiguous pyrrolidine stereogenic centers were established by single-crystal X-ray analysis.

Original languageEnglish (US)
Pages (from-to)1685-1688
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number13
DOIs
StatePublished - Mar 26 1998

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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