Synthesis of glycolipid antigens

Suvarn S. Kulkarni, Jacquelyn Gervay-Hague

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations


Carbohydrates and glycoconjugates play important roles in complex life processes. Development of carbohydrate-based therapeutics is a major focus of our laboratory requiring the synthesis of glycolipid antigens for biological evaluation. Stereoselective formation of O- and C-glycosides is one of the central challenges in carbohydrate synthesis. In this pursuit, we employ glycosyl iodides as unique glycosyl donors to construct functionally enriched appendages on the anomeric center of the sugar moiety in a highly efficient and stereoselective manner. These constructs can be used to rapidly synthesize a panoply of glycoside analogs for biological studies. In this minireview, glycosyl iodide mediated syntheses of α-linked O-glycolipids such as KRN 7000 and BbGL2 as well C-glycolipid analogs are described.

Original languageEnglish (US)
Title of host publicationACS Symposium Series
PublisherAmerican Chemical Society
Number of pages14
ISBN (Print)9780841274402
StatePublished - Sep 1 2008

Publication series

NameACS Symposium Series
ISSN (Print)00976156
ISSN (Electronic)19475918

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)


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