Synthesis of epoxide hydrolase sEH inhibitors and study of its inhibitory properties

G. M. Butov, V. V. Burmistrov, D. V. Danilov, A. D. Averin, C. Morisseau, S. Kodani, B. D. Hammock

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Adamantyl-containing 1,3-disubstituted ureas, bisureas, and biscarbamates containing different spacers between the ureylene or the carbamate groups and the adamantyl radical were synthesized. Their inhibitory activity against soluble epoxide hydrolases of mammals and humans (sEH, E.C. 3.3.2.10) was studied. The compounds were found to possess high inhibitory activity on the level of 0.8—2.7 nmol L–1. A relationship between the inhibitor structure and its activity was established.

Original languageEnglish (US)
Pages (from-to)2299-2305
Number of pages7
JournalRussian Chemical Bulletin
Volume65
Issue number9
DOIs
StatePublished - Sep 1 2016

Keywords

  • adamantane
  • carbamate
  • diurea
  • inhibition
  • isocyanate
  • soluble epoxide hydrolase
  • urea

ASJC Scopus subject areas

  • Chemistry(all)

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    Butov, G. M., Burmistrov, V. V., Danilov, D. V., Averin, A. D., Morisseau, C., Kodani, S., & Hammock, B. D. (2016). Synthesis of epoxide hydrolase sEH inhibitors and study of its inhibitory properties. Russian Chemical Bulletin, 65(9), 2299-2305. https://doi.org/10.1007/s11172-016-1581-y