Synthesis of (Dicarbonyl)(Ƞ5-cyclopentadienyl)Manganese Complex Stabilized Nucleoside Phosphite Esters

Don Bergstrom; Peter Beal; Robert Lind

doi:10.1080/07328318908054281

Synthesis of (Dicarbonyl)(Ƞ⁵-cyclopentadienyl)Manganese Complex Stabilized Nucleoside Phosphite Esters

Don Bergstrom, Peter Beal, Robert Lind

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We have found that stable nucleoside derived phosphite ester manganese complexes can be generated by the reaction of Mn(CO)₂(THF)(Ƞ⁵-C₅H₄R) with nucleoside phosphite esters. These complexes appear to be stable towards oxygen and reagents used for DNA synthesis and deprotection. The cyclopentadienyl ligand can be modified by a strong electron withdrawing group and still retain the photochemical and chemical properties necessary to complex readily to phosphite esters.

Original language	English (US)
Pages (from-to)	1061-1063
Number of pages	3
Journal	Nucleosides and Nucleotides
Volume	8
Issue number	5-6
DOIs	https://doi.org/10.1080/07328318908054281
State	Published - Jan 1 1989
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Genetics

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title = "Synthesis of (Dicarbonyl)(Ƞ5-cyclopentadienyl)Manganese Complex Stabilized Nucleoside Phosphite Esters",

abstract = "We have found that stable nucleoside derived phosphite ester manganese complexes can be generated by the reaction of Mn(CO)2(THF)(Ƞ5-C5H4R) with nucleoside phosphite esters. These complexes appear to be stable towards oxygen and reagents used for DNA synthesis and deprotection. The cyclopentadienyl ligand can be modified by a strong electron withdrawing group and still retain the photochemical and chemical properties necessary to complex readily to phosphite esters.",

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AU - Bergstrom, Don

AU - Beal, Peter

AU - Lind, Robert

PY - 1989/1/1

Y1 - 1989/1/1

N2 - We have found that stable nucleoside derived phosphite ester manganese complexes can be generated by the reaction of Mn(CO)2(THF)(Ƞ5-C5H4R) with nucleoside phosphite esters. These complexes appear to be stable towards oxygen and reagents used for DNA synthesis and deprotection. The cyclopentadienyl ligand can be modified by a strong electron withdrawing group and still retain the photochemical and chemical properties necessary to complex readily to phosphite esters.

AB - We have found that stable nucleoside derived phosphite ester manganese complexes can be generated by the reaction of Mn(CO)2(THF)(Ƞ5-C5H4R) with nucleoside phosphite esters. These complexes appear to be stable towards oxygen and reagents used for DNA synthesis and deprotection. The cyclopentadienyl ligand can be modified by a strong electron withdrawing group and still retain the photochemical and chemical properties necessary to complex readily to phosphite esters.

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