Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs

Bogdan Barnych; Amy A. Rand; Tomas Cajka; Kin Sing Stephen Lee; Bruce D. Hammock

doi:10.1039/c7ob00789b

Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs

Bogdan Barnych, Amy A. Rand, Tomas Cajka, Kin Sing Stephen Lee, Bruce D. Hammock

Entomology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.

Original language	English (US)
Pages (from-to)	4308-4313
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	15
Issue number	20
DOIs	https://doi.org/10.1039/c7ob00789b
State	Published - 2017

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs",

abstract = "COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.",

author = "Bogdan Barnych and Rand, {Amy A.} and Tomas Cajka and Lee, {Kin Sing Stephen} and Hammock, {Bruce D.}",

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T2 - 11- and 15-hydroxy 8,9-EETs

AU - Barnych, Bogdan

AU - Rand, Amy A.

AU - Cajka, Tomas

AU - Lee, Kin Sing Stephen

AU - Hammock, Bruce D.

PY - 2017

Y1 - 2017

N2 - COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.

AB - COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.

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DO - 10.1039/c7ob00789b

M3 - Article

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EP - 4313

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

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