Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs

Bogdan Barnych, Amy A. Rand, Tomas Cajka, Kin Sing Stephen Lee, Bruce D. Hammock

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.

Original languageEnglish (US)
Pages (from-to)4308-4313
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume15
Issue number20
DOIs
StatePublished - 2017

Fingerprint

metabolites
Prostaglandin-Endoperoxide Synthases
Metabolites
acids
synthesis
lipids
Lipids
8,9-epoxyeicosatrienoic acid
11-hydroxy-8,9-epoxyeicosatrienoic acid

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET) : 11- and 15-hydroxy 8,9-EETs. / Barnych, Bogdan; Rand, Amy A.; Cajka, Tomas; Lee, Kin Sing Stephen; Hammock, Bruce D.

In: Organic and Biomolecular Chemistry, Vol. 15, No. 20, 2017, p. 4308-4313.

Research output: Contribution to journalArticle

Barnych, Bogdan ; Rand, Amy A. ; Cajka, Tomas ; Lee, Kin Sing Stephen ; Hammock, Bruce D. / Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET) : 11- and 15-hydroxy 8,9-EETs. In: Organic and Biomolecular Chemistry. 2017 ; Vol. 15, No. 20. pp. 4308-4313.
@article{e0a43f424104423187f4d76a080c8f74,
title = "Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs",
abstract = "COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.",
author = "Bogdan Barnych and Rand, {Amy A.} and Tomas Cajka and Lee, {Kin Sing Stephen} and Hammock, {Bruce D.}",
year = "2017",
doi = "10.1039/c7ob00789b",
language = "English (US)",
volume = "15",
pages = "4308--4313",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "Royal Society of Chemistry",
number = "20",

}

TY - JOUR

T1 - Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET)

T2 - 11- and 15-hydroxy 8,9-EETs

AU - Barnych, Bogdan

AU - Rand, Amy A.

AU - Cajka, Tomas

AU - Lee, Kin Sing Stephen

AU - Hammock, Bruce D.

PY - 2017

Y1 - 2017

N2 - COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.

AB - COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.

UR - http://www.scopus.com/inward/record.url?scp=85021681542&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021681542&partnerID=8YFLogxK

U2 - 10.1039/c7ob00789b

DO - 10.1039/c7ob00789b

M3 - Article

AN - SCOPUS:85021681542

VL - 15

SP - 4308

EP - 4313

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

IS - 20

ER -