Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs

Bogdan Barnych, Amy A. Rand, Tomas Cajka, Kin Sing Stephen Lee, Bruce D. Hammock

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.

Original languageEnglish (US)
Pages (from-to)4308-4313
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume15
Issue number20
DOIs
StatePublished - 2017

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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