Abstract
COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4308-4313 |
| Number of pages | 6 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 15 |
| Issue number | 20 |
| DOIs | |
| State | Published - 2017 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Barnych, B., Rand, A. A., Cajka, T., Lee, K. S. S., & Hammock, B. D. (2017). Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs. Organic and Biomolecular Chemistry, 15(20), 4308-4313. https://doi.org/10.1039/c7ob00789b