Synthesis of antimicrobial natural products targeting FtsZ: (+)-totarol and related totarane diterpenes

Michelle B. Kim; Jared T. Shaw

doi:10.1021/ol100929z

Synthesis of antimicrobial natural products targeting FtsZ: (+)-totarol and related totarane diterpenes

Michelle B. Kim, Jared T. Shaw

Chemistry

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

(Equation Presented). An efficient, convergent synthesis of totarol by a diastereoselective epoxide/alkene/arene bicyclization is described. The reported synthesis enables the preparation of related diterpenes totaradiol and totarolone as well as previously unavailable derivatives that exhibit comparable inhibition of the bacterial cell division protein FtsZ.

Original language	English (US)
Pages (from-to)	3324-3327
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	15
DOIs	https://doi.org/10.1021/ol100929z
State	Published - Aug 6 2010

ASJC Scopus subject areas

Organic Chemistry
Physical and Theoretical Chemistry
Biochemistry
Medicine(all)

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10.1021/ol100929z

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title = "Synthesis of antimicrobial natural products targeting FtsZ: (+)-totarol and related totarane diterpenes",

abstract = "(Equation Presented). An efficient, convergent synthesis of totarol by a diastereoselective epoxide/alkene/arene bicyclization is described. The reported synthesis enables the preparation of related diterpenes totaradiol and totarolone as well as previously unavailable derivatives that exhibit comparable inhibition of the bacterial cell division protein FtsZ.",

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