Synthesis of antimicrobial natural products targeting FtsZ: (+)-totarol and related totarane diterpenes

Michelle B. Kim, Jared T. Shaw

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

(Equation Presented). An efficient, convergent synthesis of totarol by a diastereoselective epoxide/alkene/arene bicyclization is described. The reported synthesis enables the preparation of related diterpenes totaradiol and totarolone as well as previously unavailable derivatives that exhibit comparable inhibition of the bacterial cell division protein FtsZ.

Original languageEnglish (US)
Pages (from-to)3324-3327
Number of pages4
JournalOrganic Letters
Volume12
Issue number15
DOIs
StatePublished - Aug 6 2010

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry
  • Medicine(all)

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