Abstract
(Equation Presented). An efficient, convergent synthesis of totarol by a diastereoselective epoxide/alkene/arene bicyclization is described. The reported synthesis enables the preparation of related diterpenes totaradiol and totarolone as well as previously unavailable derivatives that exhibit comparable inhibition of the bacterial cell division protein FtsZ.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3324-3327 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 12 |
| Issue number | 15 |
| DOIs | |
| State | Published - Aug 6 2010 |
ASJC Scopus subject areas
- Organic Chemistry
- Physical and Theoretical Chemistry
- Biochemistry
- Medicine(all)
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Kim, M. B., & Shaw, J. T. (2010). Synthesis of antimicrobial natural products targeting FtsZ: (+)-totarol and related totarane diterpenes. Organic Letters, 12(15), 3324-3327. https://doi.org/10.1021/ol100929z