Abstract
(Equation Presented). An efficient, convergent synthesis of totarol by a diastereoselective epoxide/alkene/arene bicyclization is described. The reported synthesis enables the preparation of related diterpenes totaradiol and totarolone as well as previously unavailable derivatives that exhibit comparable inhibition of the bacterial cell division protein FtsZ.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3324-3327 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 12 |
| Issue number | 15 |
| DOIs | |
| State | Published - Aug 6 2010 |
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ASJC Scopus subject areas
- Organic Chemistry
- Physical and Theoretical Chemistry
- Biochemistry
- Medicine(all)
Cite this
Synthesis of antimicrobial natural products targeting FtsZ : (+)-totarol and related totarane diterpenes. / Kim, Michelle B.; Shaw, Jared T.
In: Organic Letters, Vol. 12, No. 15, 06.08.2010, p. 3324-3327.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis of antimicrobial natural products targeting FtsZ
T2 - (+)-totarol and related totarane diterpenes
AU - Kim, Michelle B.
AU - Shaw, Jared T.
PY - 2010/8/6
Y1 - 2010/8/6
N2 - (Equation Presented). An efficient, convergent synthesis of totarol by a diastereoselective epoxide/alkene/arene bicyclization is described. The reported synthesis enables the preparation of related diterpenes totaradiol and totarolone as well as previously unavailable derivatives that exhibit comparable inhibition of the bacterial cell division protein FtsZ.
AB - (Equation Presented). An efficient, convergent synthesis of totarol by a diastereoselective epoxide/alkene/arene bicyclization is described. The reported synthesis enables the preparation of related diterpenes totaradiol and totarolone as well as previously unavailable derivatives that exhibit comparable inhibition of the bacterial cell division protein FtsZ.
UR - http://www.scopus.com/inward/record.url?scp=77955138547&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955138547&partnerID=8YFLogxK
U2 - 10.1021/ol100929z
DO - 10.1021/ol100929z
M3 - Article
C2 - 20597470
AN - SCOPUS:77955138547
VL - 12
SP - 3324
EP - 3327
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 15
ER -