Synthesis of antimicrobial natural products targeting FtsZ: (±)-dichamanetin and (±)-2‴-hydroxy-5″- benzylisouvarinol-B

Sameer Urgaonkar, Henry S. La Pierre, Israel Meir, Henrik Lund, Debabrata RayChaudhuri, Jared T. Shaw

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

(Chemical Equation Presented) Two natural products have been synthesized using a ZnCl2-mediated benzylic coupling reaction. Both are potent inhibitors of the GTPase activity of FtsZ, a highly conserved protein that is essential for bacterial cytokinesis.

Original languageEnglish (US)
Pages (from-to)5609-5612
Number of pages4
JournalOrganic Letters
Volume7
Issue number25
DOIs
StatePublished - Dec 8 2005
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine

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