Synthesis of antimicrobial natural products targeting FtsZ: (±)-dichamanetin and (±)-2‴-hydroxy-5″- benzylisouvarinol-B

Sameer Urgaonkar; Henry S. La Pierre; Israel Meir; Henrik Lund; Debabrata RayChaudhuri; Jared T. Shaw

doi:10.1021/ol052269z

Synthesis of antimicrobial natural products targeting FtsZ: (±)-dichamanetin and (±)-2‴-hydroxy-5″- benzylisouvarinol-B

Sameer Urgaonkar, Henry S. La Pierre, Israel Meir, Henrik Lund, Debabrata RayChaudhuri, Jared T. Shaw

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

(Chemical Equation Presented) Two natural products have been synthesized using a ZnCl₂-mediated benzylic coupling reaction. Both are potent inhibitors of the GTPase activity of FtsZ, a highly conserved protein that is essential for bacterial cytokinesis.

Original language	English (US)
Pages (from-to)	5609-5612
Number of pages	4
Journal	Organic Letters
Volume	7
Issue number	25
DOIs	https://doi.org/10.1021/ol052269z
State	Published - Dec 8 2005
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine

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title = "Synthesis of antimicrobial natural products targeting FtsZ: (±)-dichamanetin and (±)-2‴-hydroxy-5″- benzylisouvarinol-B",

abstract = "(Chemical Equation Presented) Two natural products have been synthesized using a ZnCl2-mediated benzylic coupling reaction. Both are potent inhibitors of the GTPase activity of FtsZ, a highly conserved protein that is essential for bacterial cytokinesis.",

author = "Sameer Urgaonkar and {La Pierre}, {Henry S.} and Israel Meir and Henrik Lund and Debabrata RayChaudhuri and Shaw, {Jared T.}",

year = "2005",

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T2 - (±)-dichamanetin and (±)-2‴-hydroxy-5″- benzylisouvarinol-B

AU - Urgaonkar, Sameer

AU - La Pierre, Henry S.

AU - Meir, Israel

AU - Lund, Henrik

AU - RayChaudhuri, Debabrata

AU - Shaw, Jared T.

PY - 2005/12/8

Y1 - 2005/12/8

N2 - (Chemical Equation Presented) Two natural products have been synthesized using a ZnCl2-mediated benzylic coupling reaction. Both are potent inhibitors of the GTPase activity of FtsZ, a highly conserved protein that is essential for bacterial cytokinesis.

AB - (Chemical Equation Presented) Two natural products have been synthesized using a ZnCl2-mediated benzylic coupling reaction. Both are potent inhibitors of the GTPase activity of FtsZ, a highly conserved protein that is essential for bacterial cytokinesis.

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Synthesis of antimicrobial natural products targeting FtsZ: (±)-dichamanetin and (±)-2‴-hydroxy-5″- benzylisouvarinol-B

Abstract

ASJC Scopus subject areas

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