Synthesis of anti-inflammatory furan fatty acids from biomass-derived 5-(chloromethyl)furfural

Fei Chang, Wan Hsuan Hsu, Mark Mascal

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


An efficient synthetic approach to furan fatty acids starting from the biomass-derived platform chemical 5-(chloromethyl)furfural (CMF) is described. The route involves seven steps and has a 60% overall yield. Furan fatty acids are dietary antioxidants that occur naturally in fish and are proposed to have anti-atherosclerotic properties. The free radical scavenging abilities of synthetic furan fatty acids were evaluated against butylated hydroxytoluene (BHT) by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay.

Original languageEnglish (US)
Pages (from-to)14-18
Number of pages5
JournalSustainable Chemistry and Pharmacy
StatePublished - Jun 1 2015


  • 5-(Chloromethyl)furfural
  • Antioxidants
  • Biomass
  • Natural products
  • Synthesis

ASJC Scopus subject areas

  • Environmental Chemistry
  • Management, Monitoring, Policy and Law
  • Pollution
  • Pharmaceutical Science


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