Synthesis of alkyl 4-hydroxy-2-alkynoates

M. Mark Midland, Alfonso Tramontano, John R. Cable

Research output: Contribution to journalArticlepeer-review

121 Scopus citations


The lithium acetylide anion of ethyl or methyl propiolate is readily prepared by the addition of n-butyllithium to ethyl or methyl propiolate at low temperature. The anion rapidly adds to a variety of aldehydes or ketones to give ethyl or methyl 4-hydroxy-2-alkynoates in high yield.

Original languageEnglish (US)
Pages (from-to)28-29
Number of pages2
JournalJournal of Organic Chemistry
Issue number1
StatePublished - 1980

ASJC Scopus subject areas

  • Organic Chemistry


Dive into the research topics of 'Synthesis of alkyl 4-hydroxy-2-alkynoates'. Together they form a unique fingerprint.

Cite this