Abstract
The lithium acetylide anion of ethyl or methyl propiolate is readily prepared by the addition of n-butyllithium to ethyl or methyl propiolate at low temperature. The anion rapidly adds to a variety of aldehydes or ketones to give ethyl or methyl 4-hydroxy-2-alkynoates in high yield.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 28-29 |
| Number of pages | 2 |
| Journal | Journal of Organic Chemistry |
| Volume | 45 |
| Issue number | 1 |
| Publication status | Published - 1980 |
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ASJC Scopus subject areas
- Organic Chemistry
Cite this
Midland, M. M., Tramontano, A., & Cable, J. R. (1980). Synthesis of alkyl 4-hydroxy-2-alkynoates. Journal of Organic Chemistry, 45(1), 28-29.