Synthesis of alkyl 4-hydroxy-2-alkynoates

M. Mark Midland, Alfonso Tramontano, John R. Cable

Research output: Contribution to journalArticle

120 Scopus citations


The lithium acetylide anion of ethyl or methyl propiolate is readily prepared by the addition of n-butyllithium to ethyl or methyl propiolate at low temperature. The anion rapidly adds to a variety of aldehydes or ketones to give ethyl or methyl 4-hydroxy-2-alkynoates in high yield.

Original languageEnglish (US)
Pages (from-to)28-29
Number of pages2
JournalJournal of Organic Chemistry
Issue number1
StatePublished - 1980

ASJC Scopus subject areas

  • Organic Chemistry

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    Midland, M. M., Tramontano, A., & Cable, J. R. (1980). Synthesis of alkyl 4-hydroxy-2-alkynoates. Journal of Organic Chemistry, 45(1), 28-29.