Synthesis of alkyl 4-hydroxy-2-alkynoates

M. Mark Midland; Alfonso Tramontano; John R. Cable

Synthesis of alkyl 4-hydroxy-2-alkynoates

M. Mark Midland, Alfonso Tramontano, John R. Cable

Pediatric Nephrology

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

The lithium acetylide anion of ethyl or methyl propiolate is readily prepared by the addition of n-butyllithium to ethyl or methyl propiolate at low temperature. The anion rapidly adds to a variety of aldehydes or ketones to give ethyl or methyl 4-hydroxy-2-alkynoates in high yield.

Original language	English (US)
Pages (from-to)	28-29
Number of pages	2
Journal	Journal of Organic Chemistry
Volume	45
Issue number	1
State	Published - 1980

ASJC Scopus subject areas

Organic Chemistry

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title = "Synthesis of alkyl 4-hydroxy-2-alkynoates",

abstract = "The lithium acetylide anion of ethyl or methyl propiolate is readily prepared by the addition of n-butyllithium to ethyl or methyl propiolate at low temperature. The anion rapidly adds to a variety of aldehydes or ketones to give ethyl or methyl 4-hydroxy-2-alkynoates in high yield.",

author = "Midland, {M. Mark} and Alfonso Tramontano and Cable, {John R.}",

year = "1980",

language = "English (US)",

volume = "45",

pages = "28--29",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

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T1 - Synthesis of alkyl 4-hydroxy-2-alkynoates

AU - Midland, M. Mark

AU - Tramontano, Alfonso

AU - Cable, John R.

PY - 1980

Y1 - 1980

N2 - The lithium acetylide anion of ethyl or methyl propiolate is readily prepared by the addition of n-butyllithium to ethyl or methyl propiolate at low temperature. The anion rapidly adds to a variety of aldehydes or ketones to give ethyl or methyl 4-hydroxy-2-alkynoates in high yield.

AB - The lithium acetylide anion of ethyl or methyl propiolate is readily prepared by the addition of n-butyllithium to ethyl or methyl propiolate at low temperature. The anion rapidly adds to a variety of aldehydes or ketones to give ethyl or methyl 4-hydroxy-2-alkynoates in high yield.

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M3 - Article

AN - SCOPUS:0002085548

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

SN - 0022-3263

IS - 1

ER -

Synthesis of alkyl 4-hydroxy-2-alkynoates

Abstract

ASJC Scopus subject areas

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