The lithium acetylide anion of ethyl or methyl propiolate is readily prepared by the addition of n-butyllithium to ethyl or methyl propiolate at low temperature. The anion rapidly adds to a variety of aldehydes or ketones to give ethyl or methyl 4-hydroxy-2-alkynoates in high yield.
|Original language||English (US)|
|Number of pages||2|
|Journal||Journal of Organic Chemistry|
|Publication status||Published - 1980|
ASJC Scopus subject areas
- Organic Chemistry