Abstract
A series of adamantyl-containing 1,3-disubstituted diureas and thioureas containing different spacers between the ureylene group and the adamantyl substituent has been synthesized, their inhibitory activity against mammalian and human soluble epoxide hydrolase (sEH, E.C. 3.3.2.10) has been examined. The compounds synthesized were found to exhibit high inhibitory activity on the 0.4—2.8 nmol L-1 level. The dependence between the inhibitor structure and its activity was established.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1569-1575 |
| Number of pages | 7 |
| Journal | Russian Chemical Bulletin |
| Volume | 64 |
| Issue number | 7 |
| Publication status | Published - Jul 1 2015 |
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Keywords
- Adamantane
- Diurea
- Inhibition
- Isocyanate
- Soluble epoxide hydrolase
- Thiourea
- Urea
ASJC Scopus subject areas
- Chemistry(all)
Cite this
Butov, G. M., Burmistrov, V. V., Danilov, D. V., Pitushkin, D. A., Morisseau, C., & Hammock, B. D. (2015). Synthesis of adamantyl-containing 1,3-disubstituted diureas and thioureas, efficient targeted inhibitors of human soluble epoxide hydrolase. Russian Chemical Bulletin, 64(7), 1569-1575.