Synthesis of adamantyl-containing 1,3-disubstituted diureas and thioureas, efficient targeted inhibitors of human soluble epoxide hydrolase

G. M. Butov, V. V. Burmistrov, D. V. Danilov, D. A. Pitushkin, C. Morisseau, B. D. Hammock

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A series of adamantyl-containing 1,3-disubstituted diureas and thioureas containing different spacers between the ureylene group and the adamantyl substituent has been synthesized, their inhibitory activity against mammalian and human soluble epoxide hydrolase (sEH, E.C. 3.3.2.10) has been examined. The compounds synthesized were found to exhibit high inhibitory activity on the 0.4—2.8 nmol L-1 level. The dependence between the inhibitor structure and its activity was established.

Original languageEnglish (US)
Pages (from-to)1569-1575
Number of pages7
JournalRussian Chemical Bulletin
Volume64
Issue number7
StatePublished - Jul 1 2015

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Epoxide Hydrolases
Thiourea

Keywords

  • Adamantane
  • Diurea
  • Inhibition
  • Isocyanate
  • Soluble epoxide hydrolase
  • Thiourea
  • Urea

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Butov, G. M., Burmistrov, V. V., Danilov, D. V., Pitushkin, D. A., Morisseau, C., & Hammock, B. D. (2015). Synthesis of adamantyl-containing 1,3-disubstituted diureas and thioureas, efficient targeted inhibitors of human soluble epoxide hydrolase. Russian Chemical Bulletin, 64(7), 1569-1575.

Synthesis of adamantyl-containing 1,3-disubstituted diureas and thioureas, efficient targeted inhibitors of human soluble epoxide hydrolase. / Butov, G. M.; Burmistrov, V. V.; Danilov, D. V.; Pitushkin, D. A.; Morisseau, C.; Hammock, B. D.

In: Russian Chemical Bulletin, Vol. 64, No. 7, 01.07.2015, p. 1569-1575.

Research output: Contribution to journalArticle

Butov, GM, Burmistrov, VV, Danilov, DV, Pitushkin, DA, Morisseau, C & Hammock, BD 2015, 'Synthesis of adamantyl-containing 1,3-disubstituted diureas and thioureas, efficient targeted inhibitors of human soluble epoxide hydrolase', Russian Chemical Bulletin, vol. 64, no. 7, pp. 1569-1575.
Butov, G. M. ; Burmistrov, V. V. ; Danilov, D. V. ; Pitushkin, D. A. ; Morisseau, C. ; Hammock, B. D. / Synthesis of adamantyl-containing 1,3-disubstituted diureas and thioureas, efficient targeted inhibitors of human soluble epoxide hydrolase. In: Russian Chemical Bulletin. 2015 ; Vol. 64, No. 7. pp. 1569-1575.
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