Synthesis of adamantyl-containing 1,3-disubstituted diureas and thioureas, efficient targeted inhibitors of human soluble epoxide hydrolase

G. M. Butov; V. V. Burmistrov; D. V. Danilov; D. A. Pitushkin; C. Morisseau; B. D. Hammock

Synthesis of adamantyl-containing 1,3-disubstituted diureas and thioureas, efficient targeted inhibitors of human soluble epoxide hydrolase

G. M. Butov, V. V. Burmistrov, D. V. Danilov, D. A. Pitushkin, C. Morisseau, B. D. Hammock

Entomology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A series of adamantyl-containing 1,3-disubstituted diureas and thioureas containing different spacers between the ureylene group and the adamantyl substituent has been synthesized, their inhibitory activity against mammalian and human soluble epoxide hydrolase (sEH, E.C. 3.3.2.10) has been examined. The compounds synthesized were found to exhibit high inhibitory activity on the 0.4—2.8 nmol L^-1 level. The dependence between the inhibitor structure and its activity was established.

Original language	English (US)
Pages (from-to)	1569-1575
Number of pages	7
Journal	Russian Chemical Bulletin
Volume	64
Issue number	7
State	Published - Jul 1 2015

Keywords

Adamantane
Diurea
Inhibition
Isocyanate
Soluble epoxide hydrolase
Thiourea
Urea

ASJC Scopus subject areas

Chemistry(all)

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Synthesis of adamantyl-containing 1,3-disubstituted diureas and thioureas, efficient targeted inhibitors of human soluble epoxide hydrolase. / Butov, G. M.; Burmistrov, V. V.; Danilov, D. V.; Pitushkin, D. A.; Morisseau, C.; Hammock, B. D.

In: Russian Chemical Bulletin, Vol. 64, No. 7, 01.07.2015, p. 1569-1575.

Research output: Contribution to journal › Article › peer-review

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AU - Burmistrov, V. V.

AU - Danilov, D. V.

AU - Pitushkin, D. A.

AU - Morisseau, C.

AU - Hammock, B. D.

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N2 - A series of adamantyl-containing 1,3-disubstituted diureas and thioureas containing different spacers between the ureylene group and the adamantyl substituent has been synthesized, their inhibitory activity against mammalian and human soluble epoxide hydrolase (sEH, E.C. 3.3.2.10) has been examined. The compounds synthesized were found to exhibit high inhibitory activity on the 0.4—2.8 nmol L-1 level. The dependence between the inhibitor structure and its activity was established.

AB - A series of adamantyl-containing 1,3-disubstituted diureas and thioureas containing different spacers between the ureylene group and the adamantyl substituent has been synthesized, their inhibitory activity against mammalian and human soluble epoxide hydrolase (sEH, E.C. 3.3.2.10) has been examined. The compounds synthesized were found to exhibit high inhibitory activity on the 0.4—2.8 nmol L-1 level. The dependence between the inhibitor structure and its activity was established.

KW - Adamantane

KW - Diurea

KW - Inhibition

KW - Isocyanate

KW - Soluble epoxide hydrolase

KW - Thiourea

KW - Urea

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Synthesis of adamantyl-containing 1,3-disubstituted diureas and thioureas, efficient targeted inhibitors of human soluble epoxide hydrolase

Abstract

Keywords

ASJC Scopus subject areas

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