Synthesis of a trimeric gp120 epitope mimic conjugated to a T-helper peptide to improve antigenicity

Joan G. Schellinger, Lieza M. Danan-Leon, Jessica A. Hoch, Aemro Kassa, Indresh Srivastava, David Davis, Jacquelyn Gervay-Hague

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

A fully synthetic trivalent mimotope of gp120 conjugated to pan allelic HLA DR binding epitope was prepared using solid-phase peptide synthesis and optimized copper-catalyzed azide-alkyne cycloaddition. The methodology efficiently provides chemically uniform heteromultimeric peptide constructs with enhanced binding, avidity, and specificity toward an established HIV-neutralizing human antibody, MAb b12. The versatile synthetic strategy serves as a powerful platform for the development of synthetic peptides as potential HIV-1 vaccine candidates.

Original languageEnglish (US)
Pages (from-to)3230-3233
Number of pages4
JournalJournal of the American Chemical Society
Volume133
Issue number10
DOIs
StatePublished - Mar 16 2011

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

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