Synthesis of a new hapten for generating catalytic antibodies that activate doxorubicin prodrugs

Carlos Jiménez, Alfonso Tramontano

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

In order to assess a novel strategy for catalytic activation of a new prodrug of doxorubicin, a new hapten has been designed and prepared, which can be used to induce an immune response from which catalytic antibodies (cAbs) may be produced.

Original languageEnglish (US)
Pages (from-to)7819-7822
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number44
DOIs
StatePublished - Oct 29 2001
Externally publishedYes

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Keywords

  • Anthracyclinone
  • Antibodies
  • Antitumour compound
  • Catalysis
  • Sulfonamide

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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