Synthesis of a new hapten for generating catalytic antibodies that activate doxorubicin prodrugs

Carlos Jiménez, Alfonso Tramontano

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In order to assess a novel strategy for catalytic activation of a new prodrug of doxorubicin, a new hapten has been designed and prepared, which can be used to induce an immune response from which catalytic antibodies (cAbs) may be produced.

Original languageEnglish (US)
Pages (from-to)7819-7822
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number44
DOIs
StatePublished - Oct 29 2001
Externally publishedYes

Fingerprint

Catalytic Antibodies
Haptens
Prodrugs
Doxorubicin
Chemical activation

Keywords

  • Anthracyclinone
  • Antibodies
  • Antitumour compound
  • Catalysis
  • Sulfonamide

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis of a new hapten for generating catalytic antibodies that activate doxorubicin prodrugs. / Jiménez, Carlos; Tramontano, Alfonso.

In: Tetrahedron Letters, Vol. 42, No. 44, 29.10.2001, p. 7819-7822.

Research output: Contribution to journalArticle

Jiménez, Carlos ; Tramontano, Alfonso. / Synthesis of a new hapten for generating catalytic antibodies that activate doxorubicin prodrugs. In: Tetrahedron Letters. 2001 ; Vol. 42, No. 44. pp. 7819-7822.
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