Abstract
The synthesis of a pilot scale library of 116 structurally diverse γ-lactams is reported. The library core structure emanates from a γ-lactam forming one-pot, four-component reaction of ammonium acetate, p-methoxythiophenol, p-methoxybenzaldehyde, and maleic anhydride. Structural diversity then arises from amide coupling, thioaryl cleavage, N-functionalization, and heterocycle forming reactions on this core structure. Computational analysis reveals that the library contains molecular properties and shape diversity suitable for drug lead and biological probe discovery.
Original language | English (US) |
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Pages (from-to) | 356-362 |
Number of pages | 7 |
Journal | ACS Combinatorial Science |
Volume | 15 |
Issue number | 7 |
DOIs | |
State | Published - Jul 8 2013 |
Keywords
- γ-lactam
- amide coupling
- one-pot, four-component reaction
- synthesis
- thioaryl cleavage
ASJC Scopus subject areas
- Chemistry(all)