Synthesis of a library of 2-alkyl-3-alkyloxy-2H-indazole-6-carboxamides

Aaron D. Mills, Patrick Maloney, Elsayed Hassanein, Makhluf J. Haddadin, Mark J. Kurth

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

A library of 200 2-alkyl-3-alkyloxy-2H-indazole-6-carboxamides was synthesized using parallel solution-phase methods. The indazole cyclization reaction was optimized for library production with the best yields resulting from controlled alcohol/water solvent ratios. The key step, a heterocyclization reaction, proceeds by N,N-bond formation and delivers the 2H-indazole scaffold. Automated preparative HPLC was utilized to provide pure compounds on a 10+ mg scale.

Original languageEnglish (US)
Pages (from-to)171-177
Number of pages7
JournalJournal of Combinatorial Chemistry
Volume9
Issue number1
DOIs
StatePublished - Jan 2007

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Discrete Mathematics and Combinatorics

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    Mills, A. D., Maloney, P., Hassanein, E., Haddadin, M. J., & Kurth, M. J. (2007). Synthesis of a library of 2-alkyl-3-alkyloxy-2H-indazole-6-carboxamides. Journal of Combinatorial Chemistry, 9(1), 171-177. https://doi.org/10.1021/cc060109o