Synthesis of a heterobifunctional PEG spacer terminated with aminooxy and bromide functionality

Christopher W. Dicus, Michael H. Nantz

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A simple and efficient synthesis of a novel heterobifunctional polyethylene glycol (PEG) spacer is described. The PEG spacer reagent is terminated with aminooxy and bromide functionality for ease of conjugation to a variety of electrophiles and/or nucleophiles.

Original languageEnglish (US)
Pages (from-to)2821-2823
Number of pages3
JournalSynlett
Issue number17
DOIs
StatePublished - Oct 17 2006

Keywords

  • Aminooxy
  • Bioconjugation
  • Heterobifunctional PEG
  • Molecular recognition
  • OEG
  • Spacer

ASJC Scopus subject areas

  • Organic Chemistry

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