Synthesis of a heterobifunctional PEG spacer terminated with aminooxy and bromide functionality

Christopher W. Dicus; Michael H. Nantz

doi:10.1055/s-2006-950246

Synthesis of a heterobifunctional PEG spacer terminated with aminooxy and bromide functionality

Christopher W. Dicus, Michael H. Nantz

Chemistry

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A simple and efficient synthesis of a novel heterobifunctional polyethylene glycol (PEG) spacer is described. The PEG spacer reagent is terminated with aminooxy and bromide functionality for ease of conjugation to a variety of electrophiles and/or nucleophiles.

Original language	English (US)
Pages (from-to)	2821-2823
Number of pages	3
Journal	Synlett
Issue number	17
DOIs	https://doi.org/10.1055/s-2006-950246
State	Published - Oct 17 2006

Keywords

Aminooxy
Bioconjugation
Heterobifunctional PEG
Molecular recognition
OEG
Spacer

ASJC Scopus subject areas

Organic Chemistry

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10.1055/s-2006-950246

Cite this

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title = "Synthesis of a heterobifunctional PEG spacer terminated with aminooxy and bromide functionality",

abstract = "A simple and efficient synthesis of a novel heterobifunctional polyethylene glycol (PEG) spacer is described. The PEG spacer reagent is terminated with aminooxy and bromide functionality for ease of conjugation to a variety of electrophiles and/or nucleophiles.",

keywords = "Aminooxy, Bioconjugation, Heterobifunctional PEG, Molecular recognition, OEG, Spacer",

author = "Dicus, {Christopher W.} and Nantz, {Michael H.}",

year = "2006",

month = oct,

day = "17",

doi = "10.1055/s-2006-950246",

language = "English (US)",

pages = "2821--2823",

journal = "Synlett",

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number = "17",

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T1 - Synthesis of a heterobifunctional PEG spacer terminated with aminooxy and bromide functionality

AU - Dicus, Christopher W.

AU - Nantz, Michael H.

PY - 2006/10/17

Y1 - 2006/10/17

N2 - A simple and efficient synthesis of a novel heterobifunctional polyethylene glycol (PEG) spacer is described. The PEG spacer reagent is terminated with aminooxy and bromide functionality for ease of conjugation to a variety of electrophiles and/or nucleophiles.

AB - A simple and efficient synthesis of a novel heterobifunctional polyethylene glycol (PEG) spacer is described. The PEG spacer reagent is terminated with aminooxy and bromide functionality for ease of conjugation to a variety of electrophiles and/or nucleophiles.

KW - Aminooxy

KW - Bioconjugation

KW - Heterobifunctional PEG

KW - Molecular recognition

KW - OEG

KW - Spacer

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JO - Synlett

JF - Synlett

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IS - 17

ER -

Synthesis of a heterobifunctional PEG spacer terminated with aminooxy and bromide functionality

Abstract

Keywords

ASJC Scopus subject areas

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