TY - JOUR
T1 - Synthesis of 8-[18F]fluoroguanine derivatives
T2 - In vivo probes for imaging gene expression with positron emission tomography
AU - Namavari, Mohammad
AU - Barrio, Jorge R.
AU - Toyokuni, Tatsushi
AU - Gambhir, Sanjiv S.
AU - Cherry, Simon R
AU - Herschman, Harvey R.
AU - Phelps, Michael E.
AU - Satyamurthy, N.
PY - 2000/2
Y1 - 2000/2
N2 - A new method for the preparation of 8-[18F]fluoroguanine derivatives based on a direct radiofluorination reaction has been developed. The radiofluorination of ganciclovir (1a) with [18F]F2 was carried out in absolute ethanol in the presence of tetraethylammonium hydroxide at room temperature to give 8-[18F]fluoroganciclovir (3a) in an approximately 1% radiochemical yield. Similarly, 8-[18F]fluoropenciclovir (3b), 8-[18F]fluoroacyclovir (3c), and 8-[18F]fluoroguanosine (3d) were synthesized from penciclovir (1b), acyclovir (1c), and guanosine (1d), respectively, using [18F]F2. The structural analyses of the final products (3a, 3b, 3c, and 3d) were carried out after 18F decay by 1H, 13C, and 19F nuclear magnetic resonance and high resolution mass spectroscopy. Copyright (C) 2000 Elsevier Science Inc.
AB - A new method for the preparation of 8-[18F]fluoroguanine derivatives based on a direct radiofluorination reaction has been developed. The radiofluorination of ganciclovir (1a) with [18F]F2 was carried out in absolute ethanol in the presence of tetraethylammonium hydroxide at room temperature to give 8-[18F]fluoroganciclovir (3a) in an approximately 1% radiochemical yield. Similarly, 8-[18F]fluoropenciclovir (3b), 8-[18F]fluoroacyclovir (3c), and 8-[18F]fluoroguanosine (3d) were synthesized from penciclovir (1b), acyclovir (1c), and guanosine (1d), respectively, using [18F]F2. The structural analyses of the final products (3a, 3b, 3c, and 3d) were carried out after 18F decay by 1H, 13C, and 19F nuclear magnetic resonance and high resolution mass spectroscopy. Copyright (C) 2000 Elsevier Science Inc.
KW - 8-[F]Fluoroacyclovir
KW - 8-[F]Fluoroganciclovir
KW - 8-[F]Fluoropenciclovir
KW - Gene expression
KW - PET
UR - http://www.scopus.com/inward/record.url?scp=0033625192&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033625192&partnerID=8YFLogxK
U2 - 10.1016/S0969-8051(99)00095-5
DO - 10.1016/S0969-8051(99)00095-5
M3 - Article
C2 - 10773544
AN - SCOPUS:0033625192
VL - 27
SP - 157
EP - 162
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
SN - 0969-8051
IS - 2
ER -