Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds

Tamás Kálai, Jitka Petrlova, Mária Balog, Hnin Hnin Aung, John C Voss, Kálmán Hideg

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A series of 2-aminofluorenes N-alkylated with nitroxides or their precursors were synthesized. The new compounds were tested on hydroxyl radical and peroxyl radical scavenging ability and inflammatory assay on the endothelial brain cells. In agreement with ROS scavenging ability the same compound 7-bromo-N -[(1-Oxyl-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine-4yl)methyl]- 9H-fluoren-2-amine (3b) and its hydroxylamine salt (3b/OH/HCl) showed the anti-inflammatory property on the endothelial brain cells.

Original languageEnglish (US)
Pages (from-to)1348-1355
Number of pages8
JournalEuropean Journal of Medicinal Chemistry
Volume46
Issue number4
DOIs
StatePublished - Apr 2011

Fingerprint

Scavenging
Amyloid
Brain
Endothelial Cells
Antioxidants
Hydroxylamine
Hydroxyl Radical
Assays
Anti-Inflammatory Agents
Salts
2-aminofluorene
perhydroxyl radical

Keywords

  • Alzhemer's disease
  • Antioxidants
  • Free radicals
  • Nitroxides
  • Spin trapping

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds. / Kálai, Tamás; Petrlova, Jitka; Balog, Mária; Aung, Hnin Hnin; Voss, John C; Hideg, Kálmán.

In: European Journal of Medicinal Chemistry, Vol. 46, No. 4, 04.2011, p. 1348-1355.

Research output: Contribution to journalArticle

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AU - Hideg, Kálmán

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