Abstract
Brasilibactin A, a naturally occurring siderophore related to the mycobactins, has been synthesized in six steps. Use of asymmetric titanium-mediated aldol reactions allowed the preparation of both diastereomers from a common synthetic intermediate, thus allowing the relative stereochemistry of the natural product to be assigned. Brasilibactin A exhibits no inhibition of histone deacetylases (HDACs) in spite of the N-formyl-N-hydroxy lysine moiety that is expected to affect the activity of these metal-dependent lysine-modifying enzymes.
Original language | English (US) |
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Pages (from-to) | 1679-1681 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 9 |
Issue number | 9 |
DOIs | |
State | Published - Apr 26 2007 |
ASJC Scopus subject areas
- Molecular Medicine