Synthesis and Reactions of 7-Fluoro-4-methyl-6-nitro-2-oxo-2H-1-benzopyran- 3-carboxylic Acid: A Novel Scaffold for Combinatorial Synthesis of Coumarins

Aimin Song, Jinhua Zhang, Kit Lam

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

7-Fluoro-4-methyl-6-nitro-2-oxo-2H-1-benzopyran-3-carboxylic acid has been prepared as a novel scaffold for combinatorial synthesis of coumarins. The scaffold has three points of diversity. The optimal conditions for its reactions with different nucleophiles in solid phase were obtained. Sixteen coumarin derivatives with different structures were designed and synthesized in solid phase to demonstrate its application as a scaffold for combinatorial synthesis of coumarins. Thirteen of these derivatives were obtained in high yields. Many of these model compounds fluoresce. Combinatorial libraries constructed with this novel scaffold may have interesting biological or physical properties.

Original languageEnglish (US)
Pages (from-to)112-120
Number of pages9
JournalJournal of Combinatorial Chemistry
Volume6
Issue number1
DOIs
StatePublished - Jan 2004

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Discrete Mathematics and Combinatorics

Fingerprint Dive into the research topics of 'Synthesis and Reactions of 7-Fluoro-4-methyl-6-nitro-2-oxo-2H-1-benzopyran- 3-carboxylic Acid: A Novel Scaffold for Combinatorial Synthesis of Coumarins'. Together they form a unique fingerprint.

  • Cite this