Synthesis and properties of diadamantyl-containing symmetric diureas as target-oriented inhibitors of human soluble epoxide hydrolase

V. V. Burmistrov, G. M. Butov, D. S. Karlov, V. A. Palyulin, N. S. Zefirov, C. Morisseau, B. D. Hammock

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

A series of target-oriented competitive inhibitors of human soluble epoxide hydrolase have been synthesized. The compounds retain the inhibitory properties at concentrations down to 4 nM. Based on the results of molecular modeling, it has been shown that the high inhibitory activity of this series of compounds is achieved by a unique mode of the binding to the active site of the enzyme.

Original languageEnglish (US)
Pages (from-to)404-414
Number of pages11
JournalRussian Journal of Bioorganic Chemistry
Volume42
Issue number4
DOIs
StatePublished - Jul 1 2016

Fingerprint

Epoxide Hydrolases
Molecular modeling
Catalytic Domain
Enzymes

Keywords

  • adamantane
  • isocyanate
  • molecular modeling
  • soluble epoxide hydrolase
  • urea

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

Cite this

Burmistrov, V. V., Butov, G. M., Karlov, D. S., Palyulin, V. A., Zefirov, N. S., Morisseau, C., & Hammock, B. D. (2016). Synthesis and properties of diadamantyl-containing symmetric diureas as target-oriented inhibitors of human soluble epoxide hydrolase. Russian Journal of Bioorganic Chemistry, 42(4), 404-414. https://doi.org/10.1134/S1068162016030067

Synthesis and properties of diadamantyl-containing symmetric diureas as target-oriented inhibitors of human soluble epoxide hydrolase. / Burmistrov, V. V.; Butov, G. M.; Karlov, D. S.; Palyulin, V. A.; Zefirov, N. S.; Morisseau, C.; Hammock, B. D.

In: Russian Journal of Bioorganic Chemistry, Vol. 42, No. 4, 01.07.2016, p. 404-414.

Research output: Contribution to journal › Article

Burmistrov, VV, Butov, GM, Karlov, DS, Palyulin, VA, Zefirov, NS, Morisseau, C & Hammock, BD 2016, 'Synthesis and properties of diadamantyl-containing symmetric diureas as target-oriented inhibitors of human soluble epoxide hydrolase', Russian Journal of Bioorganic Chemistry, vol. 42, no. 4, pp. 404-414. https://doi.org/10.1134/S1068162016030067
Burmistrov VV, Butov GM, Karlov DS, Palyulin VA, Zefirov NS, Morisseau C et al. Synthesis and properties of diadamantyl-containing symmetric diureas as target-oriented inhibitors of human soluble epoxide hydrolase. Russian Journal of Bioorganic Chemistry. 2016 Jul 1;42(4):404-414. https://doi.org/10.1134/S1068162016030067
Burmistrov, V. V. ; Butov, G. M. ; Karlov, D. S. ; Palyulin, V. A. ; Zefirov, N. S. ; Morisseau, C. ; Hammock, B. D. / Synthesis and properties of diadamantyl-containing symmetric diureas as target-oriented inhibitors of human soluble epoxide hydrolase. In: Russian Journal of Bioorganic Chemistry. 2016 ; Vol. 42, No. 4. pp. 404-414.
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