Synthesis and properties of diadamantyl-containing symmetric diureas as target-oriented inhibitors of human soluble epoxide hydrolase

V. V. Burmistrov; G. M. Butov; D. S. Karlov; V. A. Palyulin; N. S. Zefirov; C. Morisseau; B. D. Hammock

doi:10.1134/S1068162016030067

Synthesis and properties of diadamantyl-containing symmetric diureas as target-oriented inhibitors of human soluble epoxide hydrolase

V. V. Burmistrov, G. M. Butov, D. S. Karlov, V. A. Palyulin, N. S. Zefirov, C. Morisseau, B. D. Hammock

Entomology

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Abstract

A series of target-oriented competitive inhibitors of human soluble epoxide hydrolase have been synthesized. The compounds retain the inhibitory properties at concentrations down to 4 nM. Based on the results of molecular modeling, it has been shown that the high inhibitory activity of this series of compounds is achieved by a unique mode of the binding to the active site of the enzyme.

Original language	English (US)
Pages (from-to)	404-414
Number of pages	11
Journal	Russian Journal of Bioorganic Chemistry
Volume	42
Issue number	4
DOIs	https://doi.org/10.1134/S1068162016030067
State	Published - Jul 1 2016

Keywords

adamantane
isocyanate
molecular modeling
soluble epoxide hydrolase
urea

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

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Synthesis and properties of diadamantyl-containing symmetric diureas as target-oriented inhibitors of human soluble epoxide hydrolase. / Burmistrov, V. V.; Butov, G. M.; Karlov, D. S.; Palyulin, V. A.; Zefirov, N. S.; Morisseau, C.; Hammock, B. D.

In: Russian Journal of Bioorganic Chemistry, Vol. 42, No. 4, 01.07.2016, p. 404-414.

Research output: Contribution to journal › Article › peer-review

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AU - Burmistrov, V. V.

AU - Butov, G. M.

AU - Karlov, D. S.

AU - Palyulin, V. A.

AU - Zefirov, N. S.

AU - Morisseau, C.

AU - Hammock, B. D.

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KW - adamantane

KW - isocyanate

KW - molecular modeling

KW - soluble epoxide hydrolase

KW - urea

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Synthesis and properties of diadamantyl-containing symmetric diureas as target-oriented inhibitors of human soluble epoxide hydrolase

Abstract

Keywords

ASJC Scopus subject areas

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