Abstract
A series of target-oriented competitive inhibitors of human soluble epoxide hydrolase have been synthesized. The compounds retain the inhibitory properties at concentrations down to 4 nM. Based on the results of molecular modeling, it has been shown that the high inhibitory activity of this series of compounds is achieved by a unique mode of the binding to the active site of the enzyme.
Original language | English (US) |
---|---|
Pages (from-to) | 404-414 |
Number of pages | 11 |
Journal | Russian Journal of Bioorganic Chemistry |
Volume | 42 |
Issue number | 4 |
DOIs | |
State | Published - Jul 1 2016 |
Keywords
- adamantane
- isocyanate
- molecular modeling
- soluble epoxide hydrolase
- urea
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry