Synthesis and properties of diadamantyl-containing symmetric diureas as target-oriented inhibitors of human soluble epoxide hydrolase

V. V. Burmistrov, G. M. Butov, D. S. Karlov, V. A. Palyulin, N. S. Zefirov, C. Morisseau, B. D. Hammock

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A series of target-oriented competitive inhibitors of human soluble epoxide hydrolase have been synthesized. The compounds retain the inhibitory properties at concentrations down to 4 nM. Based on the results of molecular modeling, it has been shown that the high inhibitory activity of this series of compounds is achieved by a unique mode of the binding to the active site of the enzyme.

Original languageEnglish (US)
Pages (from-to)404-414
Number of pages11
JournalRussian Journal of Bioorganic Chemistry
Volume42
Issue number4
DOIs
StatePublished - Jul 1 2016

Keywords

  • adamantane
  • isocyanate
  • molecular modeling
  • soluble epoxide hydrolase
  • urea

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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