Abstract
A series of target-oriented competitive inhibitors of human soluble epoxide hydrolase have been synthesized. The compounds retain the inhibitory properties at concentrations down to 4 nM. Based on the results of molecular modeling, it has been shown that the high inhibitory activity of this series of compounds is achieved by a unique mode of the binding to the active site of the enzyme.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 404-414 |
| Number of pages | 11 |
| Journal | Russian Journal of Bioorganic Chemistry |
| Volume | 42 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 1 2016 |
Keywords
- adamantane
- isocyanate
- molecular modeling
- soluble epoxide hydrolase
- urea
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
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Cite this
Burmistrov, V. V., Butov, G. M., Karlov, D. S., Palyulin, V. A., Zefirov, N. S., Morisseau, C., & Hammock, B. D. (2016). Synthesis and properties of diadamantyl-containing symmetric diureas as target-oriented inhibitors of human soluble epoxide hydrolase. Russian Journal of Bioorganic Chemistry, 42(4), 404-414. https://doi.org/10.1134/S1068162016030067