Synthesis and properties of a novel water-soluble lactose-containing polymer and its cross-linked hydrogel

Wen Jing Zhou, Mark E. Wilson, Mark J. Kurth, You Lo Hsieh, John M. Krochta, Charles F. Shoemaker

Research output: Contribution to journalArticle

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Abstract

A simple and efficient method for the synthesis of lactose-based homopolymers from lactose O-(p-vinylbenzyl)oxime (4) is described. Free radical polymerization of the new oxime monomers proceeded smoothly in an aqueous solution using potassium persulfate (KPS) and N,N,N′,N′-tetramethylethylene-diamine (TMEDA) as the initiating system and gave water-soluble homopolymers in good yields. These synthetic lactose-based polymers had high molecular weights and narrow polydispersities (Mw/Mn: 1.20-1.35) as determined by size exclusion chromatography, in conjunction with multiangle laser light scattering (SEC-MALLS). The Mark-Houwink equation was obtained as [η] = 2.15 × 10-4Mv 0.73. When the monomer was copolymerized with the cross-linking reagent N,N′-methylenebis(acrylamide) (BisA) (16% mol), hydrogels were formed which swelled as much as 21-fold in deionized water. These gels have potential applications as biocompatible materials.

Original languageEnglish (US)
Pages (from-to)7063-7068
Number of pages6
JournalMacromolecules
Volume30
Issue number23
StatePublished - Nov 17 1997

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Hydrogel
Lactose
Homopolymerization
Hydrogels
Polymers
Oximes
Monomers
Size exclusion chromatography
Water
Deionized water
Polydispersity
Free radical polymerization
Biomaterials
Light scattering
Cross-Linking Reagents
Potassium
Diamines
Gels
Acrylamide
Molecular weight

ASJC Scopus subject areas

  • Materials Chemistry

Cite this

Zhou, W. J., Wilson, M. E., Kurth, M. J., Hsieh, Y. L., Krochta, J. M., & Shoemaker, C. F. (1997). Synthesis and properties of a novel water-soluble lactose-containing polymer and its cross-linked hydrogel. Macromolecules, 30(23), 7063-7068.

Synthesis and properties of a novel water-soluble lactose-containing polymer and its cross-linked hydrogel. / Zhou, Wen Jing; Wilson, Mark E.; Kurth, Mark J.; Hsieh, You Lo; Krochta, John M.; Shoemaker, Charles F.

In: Macromolecules, Vol. 30, No. 23, 17.11.1997, p. 7063-7068.

Research output: Contribution to journalArticle

Zhou, WJ, Wilson, ME, Kurth, MJ, Hsieh, YL, Krochta, JM & Shoemaker, CF 1997, 'Synthesis and properties of a novel water-soluble lactose-containing polymer and its cross-linked hydrogel', Macromolecules, vol. 30, no. 23, pp. 7063-7068.
Zhou WJ, Wilson ME, Kurth MJ, Hsieh YL, Krochta JM, Shoemaker CF. Synthesis and properties of a novel water-soluble lactose-containing polymer and its cross-linked hydrogel. Macromolecules. 1997 Nov 17;30(23):7063-7068.
Zhou, Wen Jing ; Wilson, Mark E. ; Kurth, Mark J. ; Hsieh, You Lo ; Krochta, John M. ; Shoemaker, Charles F. / Synthesis and properties of a novel water-soluble lactose-containing polymer and its cross-linked hydrogel. In: Macromolecules. 1997 ; Vol. 30, No. 23. pp. 7063-7068.
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