A simple and efficient method for the synthesis of lactose-based homopolymers from lactose O-(p-vinylbenzyl)oxime (4) is described. Free radical polymerization of the new oxime monomers proceeded smoothly in an aqueous solution using potassium persulfate (KPS) and N,N,N′,N′-tetramethylethylene-diamine (TMEDA) as the initiating system and gave water-soluble homopolymers in good yields. These synthetic lactose-based polymers had high molecular weights and narrow polydispersities (Mw/Mn: 1.20-1.35) as determined by size exclusion chromatography, in conjunction with multiangle laser light scattering (SEC-MALLS). The Mark-Houwink equation was obtained as [η] = 2.15 × 10-4Mv 0.73. When the monomer was copolymerized with the cross-linking reagent N,N′-methylenebis(acrylamide) (BisA) (16% mol), hydrogels were formed which swelled as much as 21-fold in deionized water. These gels have potential applications as biocompatible materials.
|Original language||English (US)|
|Number of pages||6|
|State||Published - Nov 17 1997|
ASJC Scopus subject areas
- Materials Chemistry