Abstract
(Chemical Equation Presented) Synthesis of chiral spirocyclic helical compounds which mimic the molecular architecture of the potent DNA bulge binder obtained from the antitumor agent NCS-chrom has been accomplished. Structural analysis of the compounds by CD and NMR is presented. NMR titration study indicates binding of P,α-helimer (1d) at a two-base bulge site in a DNA oligomer, providing insight to the design of agents as specific probes of a bulged structure in nucleic acids.
Original language | English (US) |
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Pages (from-to) | 4833-4836 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 6 |
Issue number | 26 |
DOIs | |
State | Published - Dec 23 2004 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine