Abstract
(Chemical Equation Presented) Synthesis of chiral spirocyclic helical compounds which mimic the molecular architecture of the potent DNA bulge binder obtained from the antitumor agent NCS-chrom has been accomplished. Structural analysis of the compounds by CD and NMR is presented. NMR titration study indicates binding of P,α-helimer (1d) at a two-base bulge site in a DNA oligomer, providing insight to the design of agents as specific probes of a bulged structure in nucleic acids.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4833-4836 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 6 |
| Issue number | 26 |
| DOIs | |
| State | Published - Dec 23 2004 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Medicine
Cite this
Synthesis and NMR binding study of a chiral spirocyclic helical analogue of a natural DNA bulge binder. / Gaikwad, Nilesh W.; Hwang, Geum Sook; Goldberg, Irving H.
In: Organic Letters, Vol. 6, No. 26, 23.12.2004, p. 4833-4836.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and NMR binding study of a chiral spirocyclic helical analogue of a natural DNA bulge binder
AU - Gaikwad, Nilesh W.
AU - Hwang, Geum Sook
AU - Goldberg, Irving H.
PY - 2004/12/23
Y1 - 2004/12/23
N2 - (Chemical Equation Presented) Synthesis of chiral spirocyclic helical compounds which mimic the molecular architecture of the potent DNA bulge binder obtained from the antitumor agent NCS-chrom has been accomplished. Structural analysis of the compounds by CD and NMR is presented. NMR titration study indicates binding of P,α-helimer (1d) at a two-base bulge site in a DNA oligomer, providing insight to the design of agents as specific probes of a bulged structure in nucleic acids.
AB - (Chemical Equation Presented) Synthesis of chiral spirocyclic helical compounds which mimic the molecular architecture of the potent DNA bulge binder obtained from the antitumor agent NCS-chrom has been accomplished. Structural analysis of the compounds by CD and NMR is presented. NMR titration study indicates binding of P,α-helimer (1d) at a two-base bulge site in a DNA oligomer, providing insight to the design of agents as specific probes of a bulged structure in nucleic acids.
UR - http://www.scopus.com/inward/record.url?scp=12344310133&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12344310133&partnerID=8YFLogxK
U2 - 10.1021/ol048152c
DO - 10.1021/ol048152c
M3 - Article
C2 - 15606078
AN - SCOPUS:12344310133
VL - 6
SP - 4833
EP - 4836
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 26
ER -