Synthesis and NMR binding study of a chiral spirocyclic helical analogue of a natural DNA bulge binder

Nilesh W. Gaikwad, Geum Sook Hwang, Irving H. Goldberg

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

(Chemical Equation Presented) Synthesis of chiral spirocyclic helical compounds which mimic the molecular architecture of the potent DNA bulge binder obtained from the antitumor agent NCS-chrom has been accomplished. Structural analysis of the compounds by CD and NMR is presented. NMR titration study indicates binding of P,α-helimer (1d) at a two-base bulge site in a DNA oligomer, providing insight to the design of agents as specific probes of a bulged structure in nucleic acids.

Original languageEnglish (US)
Pages (from-to)4833-4836
Number of pages4
JournalOrganic Letters
Volume6
Issue number26
DOIs
StatePublished - Dec 23 2004
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine

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