Synthesis and hybridization property of an oligonucleotide containing a 3'-thioformacetal linked pentathymidylate

Jiancun Zhang, Jared T. Shaw, Mark D. Matteucci

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A pentathymidylate fully substituted with 3'-thioformacetal internucleotidic linkages was synthesized and subsequently incorporated into an oligonucleotide (ON) 15mer. Tm analysis was performed on the resulting ON hybridized with its complementary RNA. This duplex demonstrated slightly improved binding affinity relative to the control phosphate diester ON/RNA hybrid.

Original languageEnglish (US)
Pages (from-to)319-322
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number3
DOIs
StatePublished - Feb 8 1999
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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