Synthesis and characterization of a redox- and light-sensitive MRI contrast agent

Chuqiao Tu, Elizabeth A. Osborne, Angelique Y. Louie

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

A redox- and light-sensitive, T1-weighted magnetic resonance imaging (MRI) contrast agent, which tethers a spiropyran (SP)/merocyanine (MC) motif to a Gd-DO3A moiety was synthesized and characterized. When in the dark, the probe is in its MC form, which has an r1 relaxivity of 2.51 m M-1 s-1 (60 MHz, 37 °C). After irradiation with visible light or mixing with NADH, the probe experiences an isomerization and the r1 relaxivity decreased 18% and 26%, respectively. Additionally, the signal intensity in MRI showed an observable decrease after the compound was mixed with NADH.

Original languageEnglish (US)
Pages (from-to)1241-1246
Number of pages6
JournalTetrahedron
Volume65
Issue number7
DOIs
StatePublished - Feb 14 2009

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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