Abstract
A redox- and light-sensitive, T1-weighted magnetic resonance imaging (MRI) contrast agent, which tethers a spiropyran (SP)/merocyanine (MC) motif to a Gd-DO3A moiety was synthesized and characterized. When in the dark, the probe is in its MC form, which has an r1 relaxivity of 2.51 m M-1 s-1 (60 MHz, 37 °C). After irradiation with visible light or mixing with NADH, the probe experiences an isomerization and the r1 relaxivity decreased 18% and 26%, respectively. Additionally, the signal intensity in MRI showed an observable decrease after the compound was mixed with NADH.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1241-1246 |
| Number of pages | 6 |
| Journal | Tetrahedron |
| Volume | 65 |
| Issue number | 7 |
| DOIs | |
| State | Published - Feb 14 2009 |
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ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
Cite this
Synthesis and characterization of a redox- and light-sensitive MRI contrast agent. / Tu, Chuqiao; Osborne, Elizabeth A.; Louie, Angelique Y.
In: Tetrahedron, Vol. 65, No. 7, 14.02.2009, p. 1241-1246.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Synthesis and characterization of a redox- and light-sensitive MRI contrast agent
AU - Tu, Chuqiao
AU - Osborne, Elizabeth A.
AU - Louie, Angelique Y.
PY - 2009/2/14
Y1 - 2009/2/14
N2 - A redox- and light-sensitive, T1-weighted magnetic resonance imaging (MRI) contrast agent, which tethers a spiropyran (SP)/merocyanine (MC) motif to a Gd-DO3A moiety was synthesized and characterized. When in the dark, the probe is in its MC form, which has an r1 relaxivity of 2.51 m M-1 s-1 (60 MHz, 37 °C). After irradiation with visible light or mixing with NADH, the probe experiences an isomerization and the r1 relaxivity decreased 18% and 26%, respectively. Additionally, the signal intensity in MRI showed an observable decrease after the compound was mixed with NADH.
AB - A redox- and light-sensitive, T1-weighted magnetic resonance imaging (MRI) contrast agent, which tethers a spiropyran (SP)/merocyanine (MC) motif to a Gd-DO3A moiety was synthesized and characterized. When in the dark, the probe is in its MC form, which has an r1 relaxivity of 2.51 m M-1 s-1 (60 MHz, 37 °C). After irradiation with visible light or mixing with NADH, the probe experiences an isomerization and the r1 relaxivity decreased 18% and 26%, respectively. Additionally, the signal intensity in MRI showed an observable decrease after the compound was mixed with NADH.
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UR - http://www.scopus.com/inward/citedby.url?scp=58149328379&partnerID=8YFLogxK
U2 - 10.1016/j.tet.2008.12.020
DO - 10.1016/j.tet.2008.12.020
M3 - Article
AN - SCOPUS:58149328379
VL - 65
SP - 1241
EP - 1246
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 7
ER -