Abstract
A redox- and light-sensitive, T1-weighted magnetic resonance imaging (MRI) contrast agent, which tethers a spiropyran (SP)/merocyanine (MC) motif to a Gd-DO3A moiety was synthesized and characterized. When in the dark, the probe is in its MC form, which has an r1 relaxivity of 2.51 m M-1 s-1 (60 MHz, 37 °C). After irradiation with visible light or mixing with NADH, the probe experiences an isomerization and the r1 relaxivity decreased 18% and 26%, respectively. Additionally, the signal intensity in MRI showed an observable decrease after the compound was mixed with NADH.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1241-1246 |
| Number of pages | 6 |
| Journal | Tetrahedron |
| Volume | 65 |
| Issue number | 7 |
| DOIs | |
| State | Published - Feb 14 2009 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
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Tu, C., Osborne, E. A., & Louie, A. Y. (2009). Synthesis and characterization of a redox- and light-sensitive MRI contrast agent. Tetrahedron, 65(7), 1241-1246. https://doi.org/10.1016/j.tet.2008.12.020