TY - JOUR
T1 - Synthesis and characterization of a redox- and light-sensitive MRI contrast agent
AU - Tu, Chuqiao
AU - Osborne, Elizabeth A.
AU - Louie, Angelique Y.
PY - 2009/2/14
Y1 - 2009/2/14
N2 - A redox- and light-sensitive, T1-weighted magnetic resonance imaging (MRI) contrast agent, which tethers a spiropyran (SP)/merocyanine (MC) motif to a Gd-DO3A moiety was synthesized and characterized. When in the dark, the probe is in its MC form, which has an r1 relaxivity of 2.51 m M-1 s-1 (60 MHz, 37 °C). After irradiation with visible light or mixing with NADH, the probe experiences an isomerization and the r1 relaxivity decreased 18% and 26%, respectively. Additionally, the signal intensity in MRI showed an observable decrease after the compound was mixed with NADH.
AB - A redox- and light-sensitive, T1-weighted magnetic resonance imaging (MRI) contrast agent, which tethers a spiropyran (SP)/merocyanine (MC) motif to a Gd-DO3A moiety was synthesized and characterized. When in the dark, the probe is in its MC form, which has an r1 relaxivity of 2.51 m M-1 s-1 (60 MHz, 37 °C). After irradiation with visible light or mixing with NADH, the probe experiences an isomerization and the r1 relaxivity decreased 18% and 26%, respectively. Additionally, the signal intensity in MRI showed an observable decrease after the compound was mixed with NADH.
UR - http://www.scopus.com/inward/record.url?scp=58149328379&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58149328379&partnerID=8YFLogxK
U2 - 10.1016/j.tet.2008.12.020
DO - 10.1016/j.tet.2008.12.020
M3 - Article
AN - SCOPUS:58149328379
VL - 65
SP - 1241
EP - 1246
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 7
ER -