Synthesis and bioassay of carbamate inhibitors of the juvenile hormone hydrolyzing esterases from the housefly, Musca domestica

Susanne M. Mumby, Bruce D. Hammock, Thomas C. Sparks, Kenji Ota

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Twenty N-alkyl carbamate derivatives of geranyl phenyl ethers were synthesized and tested for juvenile hormone and anti-juvenile hormone activity against Oncopeltus fasciatus, Lygus lineolaris, Trichoplusia ni, Tenebrio molitor, Culex pipens quinquefasciatus, and Musca domestica. Low juvenile hormone-like activity was found on only the Diptera. The compounds were also assayed as inhibitors of the esterases which hydrolyze juvenile hormone in Blaberus giganteus, T. ni, and M. domestica. Negligible inhibition of B. giganteus and T. ni esterases was found, but the meta-substituted carbamates proved to be very potent inhibitors of M. domestica juvenile hormone esterases, as were some N-alkyl carbamates of 1-naphthol.

Original languageEnglish (US)
Pages (from-to)763-765
Number of pages3
JournalJournal of Agricultural and Food Chemistry
Volume27
Issue number4
StatePublished - 1979

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Chemistry (miscellaneous)

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