Synthesis and antiulcer activity of 3, 4-dihydro-hainanensine analogs

Ruiwu Liu, Yousong Gao, Shouren Zhang, Xiaotian Liang

Research output: Contribution to journalArticle

Abstract

In order to search for new compounds with new mode of action, high antiulcer activity and lower toxicity, 26(13 pairs of diastereoisomer A and B) 3, 4-dihydro-hananensine analogs were synthesized. All compounds were tested in M1 receptor combined assay and gastric ulcer induced by cold-immersion stress in rats. Most compounds showed antiulcer activity, among them IX3A, IX7A, IX8A, IX12A, IX12B and IX13A exhibited more potent antiulcer activity than the control compound cimetidine. Meanwhile, the relationship between their structures and activity was discussed.

Original languageEnglish (US)
Pages (from-to)682-687
Number of pages6
JournalYaoxue Xuebao
Volume33
Issue number9
StatePublished - Sep 1998
Externally publishedYes

Fingerprint

Cimetidine
Immersion
Stomach Ulcer
hainanensine

Keywords

  • 3, 4-Dihydro-hainanensine analogs
  • Antiulcer activity
  • Sar studies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Liu, R., Gao, Y., Zhang, S., & Liang, X. (1998). Synthesis and antiulcer activity of 3, 4-dihydro-hainanensine analogs. Yaoxue Xuebao, 33(9), 682-687.

Synthesis and antiulcer activity of 3, 4-dihydro-hainanensine analogs. / Liu, Ruiwu; Gao, Yousong; Zhang, Shouren; Liang, Xiaotian.

In: Yaoxue Xuebao, Vol. 33, No. 9, 09.1998, p. 682-687.

Research output: Contribution to journalArticle

Liu, R, Gao, Y, Zhang, S & Liang, X 1998, 'Synthesis and antiulcer activity of 3, 4-dihydro-hainanensine analogs', Yaoxue Xuebao, vol. 33, no. 9, pp. 682-687.
Liu, Ruiwu ; Gao, Yousong ; Zhang, Shouren ; Liang, Xiaotian. / Synthesis and antiulcer activity of 3, 4-dihydro-hainanensine analogs. In: Yaoxue Xuebao. 1998 ; Vol. 33, No. 9. pp. 682-687.
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