Synthesis and analysis of RNA containing 6-trifluoromethylpurine ribonucleoside

Eduardo A. Véliz, Olen M. Stephens, Peter A. Beal

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Abstract

matrix presented We report the synthesis of a 5′-DMT-2′-TBDMS-protected phosphoramidite of 6-trifluoromethylpurine ribonucleoside (TFMP) and its use in the site-specific incorporation of 6-trifluoromethylpurine into RNA. Properties of TFMP-substituted RNA suggest it will be valuable in the study of RNA structure and the binding of RNA-modifying enzymes, particularly the RNA-editing adenosine deaminases.

Original languageEnglish (US)
Pages (from-to)2969-2971
Number of pages3
JournalOrganic Letters
Volume3
Issue number19
DOIs
StatePublished - Sep 20 2001
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Medicine

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