Synthesis and analysis of RNA containing 6-trifluoromethylpurine ribonucleoside

Eduardo A. Véliz, Olen M. Stephens, Peter A. Beal

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

matrix presented We report the synthesis of a 5′-DMT-2′-TBDMS-protected phosphoramidite of 6-trifluoromethylpurine ribonucleoside (TFMP) and its use in the site-specific incorporation of 6-trifluoromethylpurine into RNA. Properties of TFMP-substituted RNA suggest it will be valuable in the study of RNA structure and the binding of RNA-modifying enzymes, particularly the RNA-editing adenosine deaminases.

Original languageEnglish (US)
Pages (from-to)2969-2971
Number of pages3
JournalOrganic Letters
Volume3
Issue number19
DOIs
StatePublished - Sep 20 2001
Externally publishedYes

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Ribonucleosides
adenosines
editing
enzymes
RNA
synthesis
matrices
RNA Editing
Adenosine Deaminase
Enzymes

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Synthesis and analysis of RNA containing 6-trifluoromethylpurine ribonucleoside. / Véliz, Eduardo A.; Stephens, Olen M.; Beal, Peter A.

In: Organic Letters, Vol. 3, No. 19, 20.09.2001, p. 2969-2971.

Research output: Contribution to journalArticle

Véliz, Eduardo A. ; Stephens, Olen M. ; Beal, Peter A. / Synthesis and analysis of RNA containing 6-trifluoromethylpurine ribonucleoside. In: Organic Letters. 2001 ; Vol. 3, No. 19. pp. 2969-2971.
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