Abstract
Statins, anti-hypercholesterolemic agents, have previously been reported to induce apoptosis and exert antitumor activity when combined with other antitumor agents. The potential of lovastatin in combination with highly specific COX-2 inhibitor (MF-tricyclic) to induce antiproliferative activity against tumour cells was evaluated using the combination index (CI) method. Murine colorectal cancer (colon-26, CMT-93), melanoma (B16F10) and human bladder carcinoma cells (T24) were tested. Exposure of colon-26 and CMT-93 cells resulted in synergistic interactions in both cell lines with CI<1 for 20-80% inhibition of cell growth in both cell lines. This synergy was not observed in the B16F10 melanoma and T24 bladder carcinoma cells. MF-tricyclic (40 μg/ml), augmented lovastatin-induced apoptosis up to 2.5-fold in colon-26 cancer cells. Combination of a specific COX-2 inhibitor, MF-tricyclic, may increase antiproliferative effects of lovastatin in colon cancer cells and this effect was due to an augmented apoptosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 879-885 |
| Number of pages | 7 |
| Journal | Oncology Reports |
| Volume | 9 |
| Issue number | 4 |
| State | Published - Jul 2002 |
| Externally published | Yes |
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Keywords
- Apoptosis
- Colorectal cancer
- COX-2 inhibitors
- Lovastatin
- Synergism
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Synergistic interaction between highly specific cyclooxygenase-2 inhibitor, MF-tricyclic and lovastatin in murine colorectal cancer cell lines. / Feleszko, Wojciech; Jalili, Ahmad; Olszewska, Dominika; Mlynarczuk, Izabela; Grzela, Tomasz; Giermasz, Adam; Jakóbisiak, Marek.
In: Oncology Reports, Vol. 9, No. 4, 07.2002, p. 879-885.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synergistic interaction between highly specific cyclooxygenase-2 inhibitor, MF-tricyclic and lovastatin in murine colorectal cancer cell lines
AU - Feleszko, Wojciech
AU - Jalili, Ahmad
AU - Olszewska, Dominika
AU - Mlynarczuk, Izabela
AU - Grzela, Tomasz
AU - Giermasz, Adam
AU - Jakóbisiak, Marek
PY - 2002/7
Y1 - 2002/7
N2 - Statins, anti-hypercholesterolemic agents, have previously been reported to induce apoptosis and exert antitumor activity when combined with other antitumor agents. The potential of lovastatin in combination with highly specific COX-2 inhibitor (MF-tricyclic) to induce antiproliferative activity against tumour cells was evaluated using the combination index (CI) method. Murine colorectal cancer (colon-26, CMT-93), melanoma (B16F10) and human bladder carcinoma cells (T24) were tested. Exposure of colon-26 and CMT-93 cells resulted in synergistic interactions in both cell lines with CI<1 for 20-80% inhibition of cell growth in both cell lines. This synergy was not observed in the B16F10 melanoma and T24 bladder carcinoma cells. MF-tricyclic (40 μg/ml), augmented lovastatin-induced apoptosis up to 2.5-fold in colon-26 cancer cells. Combination of a specific COX-2 inhibitor, MF-tricyclic, may increase antiproliferative effects of lovastatin in colon cancer cells and this effect was due to an augmented apoptosis.
AB - Statins, anti-hypercholesterolemic agents, have previously been reported to induce apoptosis and exert antitumor activity when combined with other antitumor agents. The potential of lovastatin in combination with highly specific COX-2 inhibitor (MF-tricyclic) to induce antiproliferative activity against tumour cells was evaluated using the combination index (CI) method. Murine colorectal cancer (colon-26, CMT-93), melanoma (B16F10) and human bladder carcinoma cells (T24) were tested. Exposure of colon-26 and CMT-93 cells resulted in synergistic interactions in both cell lines with CI<1 for 20-80% inhibition of cell growth in both cell lines. This synergy was not observed in the B16F10 melanoma and T24 bladder carcinoma cells. MF-tricyclic (40 μg/ml), augmented lovastatin-induced apoptosis up to 2.5-fold in colon-26 cancer cells. Combination of a specific COX-2 inhibitor, MF-tricyclic, may increase antiproliferative effects of lovastatin in colon cancer cells and this effect was due to an augmented apoptosis.
KW - Apoptosis
KW - Colorectal cancer
KW - COX-2 inhibitors
KW - Lovastatin
KW - Synergism
UR - http://www.scopus.com/inward/record.url?scp=0036636836&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036636836&partnerID=8YFLogxK
M3 - Article
C2 - 12066226
AN - SCOPUS:0036636836
VL - 9
SP - 879
EP - 885
JO - Oncology Reports
JF - Oncology Reports
SN - 1021-335X
IS - 4
ER -