Synergistic effects of conjugated linoleic acid and chromium picolinate improve vascular function and renal pathophysiology in the insulin-resistant JCR: LA-cp rat

S. D. Proctor, S. E. Kelly, Kimber Stanhope, Peter J Havel, Jim C. Russell

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Aims: Conjugated linoleic acid (CLA) is a natural constituent of dairy products, specific isomers of which have recently been found to have insulin sensitizing and possible antiobesity actions. Chromium is a micronutrient which, as the picolinate (CrP), has been shown to increase insulin sensitivity in animal models, including the JCR:LA-cp rat. We tested the hypothesis that these agents may have beneficial synergistic effects on the micro- and macrovasculopathy associated with hyperinsulinaemia and early type 2 diabetes. Methods: Insulin-resistant cp/cp rats of the JCR:LA-cp strain were treated with mixed isomers of CLA (1.5% w/w in the chow) and/or CrP at 80 μg/kg/day (expressed as Cr) from 4 weeks of age to 12 weeks of age. Plasma insulin, lipid and adiponectin levels, aortic vascular function, renal function and glomerular sclerosis were assessed. Results: CLA administration reduced food intake, body weight and fasting insulin in JCR:LA-cp rats. Plasma adiponectin levels were significantly elevated in rats treated with both CLA and CrP. Aortic hypercontractility was reduced and the relaxant response to the nitric oxide-releasing agent acetylcholine (Ach) was increased in CrP-treated rats. Striking reductions were also observed in the level of urinary albumin and the severity of glomerular sclerosis in rats treated specifically with CLA. Conclusions: CLA and CrP have beneficial effects ameliorating several of the pathophysiologic features of an insulin-resistant rat model. These supplements may be useful adjuncts in the management of patients with the metabolic syndrome and warrant further study.

Original languageEnglish (US)
Pages (from-to)87-95
Number of pages9
JournalDiabetes, Obesity and Metabolism
Volume9
Issue number1
DOIs
StatePublished - Jan 2007

Fingerprint

Conjugated Linoleic Acids
Blood Vessels
Insulin
Kidney
Adiponectin
Sclerosis
Dairy Products
Micronutrients
Hyperinsulinism
Chromium
picolinic acid
Type 2 Diabetes Mellitus
Cholinergic Agents
Insulin Resistance
Albumins
Fasting
Nitric Oxide
Animal Models
Eating
Body Weight

Keywords

  • Adiponectin
  • Chromium
  • Conjugated linoleic acid
  • Glomerular sclerosis
  • Insulin resistance
  • JCR:LA-cp rat
  • Metabolic syndrome
  • Prediabetes
  • Vasculopathy

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Synergistic effects of conjugated linoleic acid and chromium picolinate improve vascular function and renal pathophysiology in the insulin-resistant JCR : LA-cp rat. / Proctor, S. D.; Kelly, S. E.; Stanhope, Kimber; Havel, Peter J; Russell, Jim C.

In: Diabetes, Obesity and Metabolism, Vol. 9, No. 1, 01.2007, p. 87-95.

Research output: Contribution to journalArticle

@article{67eec63e539e4010bb76cd0d4a6aefcd,
title = "Synergistic effects of conjugated linoleic acid and chromium picolinate improve vascular function and renal pathophysiology in the insulin-resistant JCR: LA-cp rat",
abstract = "Aims: Conjugated linoleic acid (CLA) is a natural constituent of dairy products, specific isomers of which have recently been found to have insulin sensitizing and possible antiobesity actions. Chromium is a micronutrient which, as the picolinate (CrP), has been shown to increase insulin sensitivity in animal models, including the JCR:LA-cp rat. We tested the hypothesis that these agents may have beneficial synergistic effects on the micro- and macrovasculopathy associated with hyperinsulinaemia and early type 2 diabetes. Methods: Insulin-resistant cp/cp rats of the JCR:LA-cp strain were treated with mixed isomers of CLA (1.5{\%} w/w in the chow) and/or CrP at 80 μg/kg/day (expressed as Cr) from 4 weeks of age to 12 weeks of age. Plasma insulin, lipid and adiponectin levels, aortic vascular function, renal function and glomerular sclerosis were assessed. Results: CLA administration reduced food intake, body weight and fasting insulin in JCR:LA-cp rats. Plasma adiponectin levels were significantly elevated in rats treated with both CLA and CrP. Aortic hypercontractility was reduced and the relaxant response to the nitric oxide-releasing agent acetylcholine (Ach) was increased in CrP-treated rats. Striking reductions were also observed in the level of urinary albumin and the severity of glomerular sclerosis in rats treated specifically with CLA. Conclusions: CLA and CrP have beneficial effects ameliorating several of the pathophysiologic features of an insulin-resistant rat model. These supplements may be useful adjuncts in the management of patients with the metabolic syndrome and warrant further study.",
keywords = "Adiponectin, Chromium, Conjugated linoleic acid, Glomerular sclerosis, Insulin resistance, JCR:LA-cp rat, Metabolic syndrome, Prediabetes, Vasculopathy",
author = "Proctor, {S. D.} and Kelly, {S. E.} and Kimber Stanhope and Havel, {Peter J} and Russell, {Jim C.}",
year = "2007",
month = "1",
doi = "10.1111/j.1463-1326.2006.00578.x",
language = "English (US)",
volume = "9",
pages = "87--95",
journal = "Diabetes, Obesity and Metabolism",
issn = "1462-8902",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Synergistic effects of conjugated linoleic acid and chromium picolinate improve vascular function and renal pathophysiology in the insulin-resistant JCR

T2 - LA-cp rat

AU - Proctor, S. D.

AU - Kelly, S. E.

AU - Stanhope, Kimber

AU - Havel, Peter J

AU - Russell, Jim C.

PY - 2007/1

Y1 - 2007/1

N2 - Aims: Conjugated linoleic acid (CLA) is a natural constituent of dairy products, specific isomers of which have recently been found to have insulin sensitizing and possible antiobesity actions. Chromium is a micronutrient which, as the picolinate (CrP), has been shown to increase insulin sensitivity in animal models, including the JCR:LA-cp rat. We tested the hypothesis that these agents may have beneficial synergistic effects on the micro- and macrovasculopathy associated with hyperinsulinaemia and early type 2 diabetes. Methods: Insulin-resistant cp/cp rats of the JCR:LA-cp strain were treated with mixed isomers of CLA (1.5% w/w in the chow) and/or CrP at 80 μg/kg/day (expressed as Cr) from 4 weeks of age to 12 weeks of age. Plasma insulin, lipid and adiponectin levels, aortic vascular function, renal function and glomerular sclerosis were assessed. Results: CLA administration reduced food intake, body weight and fasting insulin in JCR:LA-cp rats. Plasma adiponectin levels were significantly elevated in rats treated with both CLA and CrP. Aortic hypercontractility was reduced and the relaxant response to the nitric oxide-releasing agent acetylcholine (Ach) was increased in CrP-treated rats. Striking reductions were also observed in the level of urinary albumin and the severity of glomerular sclerosis in rats treated specifically with CLA. Conclusions: CLA and CrP have beneficial effects ameliorating several of the pathophysiologic features of an insulin-resistant rat model. These supplements may be useful adjuncts in the management of patients with the metabolic syndrome and warrant further study.

AB - Aims: Conjugated linoleic acid (CLA) is a natural constituent of dairy products, specific isomers of which have recently been found to have insulin sensitizing and possible antiobesity actions. Chromium is a micronutrient which, as the picolinate (CrP), has been shown to increase insulin sensitivity in animal models, including the JCR:LA-cp rat. We tested the hypothesis that these agents may have beneficial synergistic effects on the micro- and macrovasculopathy associated with hyperinsulinaemia and early type 2 diabetes. Methods: Insulin-resistant cp/cp rats of the JCR:LA-cp strain were treated with mixed isomers of CLA (1.5% w/w in the chow) and/or CrP at 80 μg/kg/day (expressed as Cr) from 4 weeks of age to 12 weeks of age. Plasma insulin, lipid and adiponectin levels, aortic vascular function, renal function and glomerular sclerosis were assessed. Results: CLA administration reduced food intake, body weight and fasting insulin in JCR:LA-cp rats. Plasma adiponectin levels were significantly elevated in rats treated with both CLA and CrP. Aortic hypercontractility was reduced and the relaxant response to the nitric oxide-releasing agent acetylcholine (Ach) was increased in CrP-treated rats. Striking reductions were also observed in the level of urinary albumin and the severity of glomerular sclerosis in rats treated specifically with CLA. Conclusions: CLA and CrP have beneficial effects ameliorating several of the pathophysiologic features of an insulin-resistant rat model. These supplements may be useful adjuncts in the management of patients with the metabolic syndrome and warrant further study.

KW - Adiponectin

KW - Chromium

KW - Conjugated linoleic acid

KW - Glomerular sclerosis

KW - Insulin resistance

KW - JCR:LA-cp rat

KW - Metabolic syndrome

KW - Prediabetes

KW - Vasculopathy

UR - http://www.scopus.com/inward/record.url?scp=33845548609&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845548609&partnerID=8YFLogxK

U2 - 10.1111/j.1463-1326.2006.00578.x

DO - 10.1111/j.1463-1326.2006.00578.x

M3 - Article

C2 - 17199723

AN - SCOPUS:33845548609

VL - 9

SP - 87

EP - 95

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

SN - 1462-8902

IS - 1

ER -