Synchronous indolent primary gastrointestinal lymphomas managed successfully with conservative measures

Andrew S. Brohl, Joo Y. Song, Ron Lieberman, Barry Gause

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We report the case of a 65-year-old man who presented with epigastric pain and guaic-positive stool. Upper and lower endoscopy revealed abnormalities in the gastric antrum and terminal ileum. Biopsy of these sites revealed histologically and immunophenotypically distinct lymphomas: gastric extranodal marginal zone lymphoma in the background of Helicobacter pylori infection and follicular lymphoma of the terminal ileum. After treatment with an H. pylori eradication regimen, repeat endoscopy showed resolution of the gastric extranodal marginal zone lymphoma and persistence of the ileal follicular lymphoma. Interestingly, molecular studies performed on the biopsy specimens revealed a common IgH rearrangement, suggesting a common precursor cell responsible for these two malignant processes. We present this unique case with a review of the literature, highlighting treatment principles for these two subtypes of indolent gastrointestinal non-Hodgkin lymphoma.

Original languageEnglish (US)
Pages (from-to)549-553
Number of pages5
JournalAmerican Journal of Therapeutics
Volume20
Issue number5
DOIs
StatePublished - Sep 2013
Externally publishedYes

Fingerprint

Follicular Lymphoma
Ileum
Helicobacter pylori
Endoscopy
Lymphoma
Biopsy
Pyloric Antrum
Helicobacter Infections
Non-Hodgkin's Lymphoma
Stomach
Pain
Therapeutics
Familial primary gastric lymphoma

Keywords

  • Extranodal marginal zone lymphoma
  • Follicular lymphoma
  • Helicobacter pylori
  • MALT

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Medicine(all)

Cite this

Synchronous indolent primary gastrointestinal lymphomas managed successfully with conservative measures. / Brohl, Andrew S.; Song, Joo Y.; Lieberman, Ron; Gause, Barry.

In: American Journal of Therapeutics, Vol. 20, No. 5, 09.2013, p. 549-553.

Research output: Contribution to journalArticle

Brohl, Andrew S. ; Song, Joo Y. ; Lieberman, Ron ; Gause, Barry. / Synchronous indolent primary gastrointestinal lymphomas managed successfully with conservative measures. In: American Journal of Therapeutics. 2013 ; Vol. 20, No. 5. pp. 549-553.
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