Synchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality

Michael S. Anglesio, Yi Kan Wang, Madlen Maassen, Hugo M. Horlings, Ali Bashashati, Janine Senz, Robertson Mackenzie, Diljot S. Grewal, Hector Li-Chang, Anthony Karnezis, Brandon S. Sheffield, Melissa K. McConechy, Friedrich Kommoss, Florin A. Taran, Annette Staebler, Sohrab P. Shah, Diethelm Wallwiener, Sara Brucker, C. Blake Gilks, Stefan KommossDavid G. Huntsman

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58 Scopus citations

Abstract

Many women with ovarian endometrioid carcinoma present with concurrent endometrial carcinoma. Organ-confined and low-grade synchronous endometrial and ovarian tumors (SEOs) clinically behave as independent primary tumors rather than a single advanced-stage carcinoma. We used 18 SEOs to investigate the ancestral relationship between the endometrial and ovarian components. Based on both targeted and exome sequencing, 17 of 18 patient cases of simultaneous cancer of the endometrium and ovary from our series showed evidence of a clonal relationship, ie, primary tumor and metastasis. Eleven patient cases fulfilled clinicopathological criteria that would lead to classification as independent endometrial and ovarian primary carcinomas, including being of FIGO stage T1a/1A, with organ-restricted growth and without surface involvement; 10 of 11 of these cases showed evidence of clonality. Our observations suggest that the disseminating cells amongst SEOs are restricted to physically accessible and microenvironment-compatible sites yet remain indolent, without the capacity for further dissemination.

Original languageEnglish (US)
Article numberdjv428
JournalJournal of the National Cancer Institute
Volume108
Issue number6
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Anglesio, M. S., Wang, Y. K., Maassen, M., Horlings, H. M., Bashashati, A., Senz, J., Mackenzie, R., Grewal, D. S., Li-Chang, H., Karnezis, A., Sheffield, B. S., McConechy, M. K., Kommoss, F., Taran, F. A., Staebler, A., Shah, S. P., Wallwiener, D., Brucker, S., Gilks, C. B., ... Huntsman, D. G. (2016). Synchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality. Journal of the National Cancer Institute, 108(6), [djv428]. https://doi.org/10.1093/jnci/djv428