Synaptic vesicles: Key organelles involved in neurotransmission

R. Jahn, Johannes W Hell, P. R. Maycox

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This article summarizes some of the recent advances in the understanding of structural and functional properties of isolated small synaptic vesicles (SSV) from mammalian brain. SSV contain a set of integral membrnae proteins which are highly specific for this organelle and which occur on all SSV of the central and peripheral nervous system irrespective of their transmitter content. In contrast, these proteins are absent from the membrane of peptide-containing large dense-core vesicles indicating that the two type of organelle have a different membrane composition. The availability of antibodies for these proteins has allowed the evaluation of the purity of vesicle preparations which is instrumental for functional studies. Recent advances in the study of neurotransmitter uptake have revealed that SSV contain specific carrier systems for glutamate and GABA. They are different from the transporters of the plasma membrane, and are dependent on the energy of a proton electrochemical gradient. The uptake of glutamate has been characterized in some detail and the mechanistic and physiological implications of these findings are discussed.

Original languageEnglish (US)
Pages (from-to)128-133
Number of pages6
JournalJournal de Physiologie
Volume84
Issue number1
StatePublished - 1990
Externally publishedYes

Fingerprint

Synaptic Vesicles
Synaptic Transmission
Organelles
Glutamic Acid
Peripheral Nervous System
Secretory Vesicles
gamma-Aminobutyric Acid
Neurotransmitter Agents
Protons
Membrane Proteins
Proteins
Central Nervous System
Cell Membrane
Peptides
Membranes
Antibodies
Brain

Keywords

  • Gaba
  • Glutamate
  • Neurotransmission
  • Synaptic vesicles

ASJC Scopus subject areas

  • Physiology

Cite this

Synaptic vesicles : Key organelles involved in neurotransmission. / Jahn, R.; Hell, Johannes W; Maycox, P. R.

In: Journal de Physiologie, Vol. 84, No. 1, 1990, p. 128-133.

Research output: Contribution to journalArticle

Jahn, R. ; Hell, Johannes W ; Maycox, P. R. / Synaptic vesicles : Key organelles involved in neurotransmission. In: Journal de Physiologie. 1990 ; Vol. 84, No. 1. pp. 128-133.
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