Abstract
Simultaneous intracellular recordings were made in the dentate gyrus of rat hippocampal slices, from pairs of the following cell types: granule cells, interneurons located in the granule cell layer, hilar interneurons, and spiny hilar "mossy cells". Granule cells were found to have strong excitatory effects on mossy cells and interneurons. Interneurons inhibited granule cells as well as other interneurons. No synaptic connections from mossy cells onto other cell types were found, within the confines of the slice, using intracellular recording methods. However, at the ultrastructural level, axon terminals of horseradish peroxidase-filled mossy cells were found making synaptic contacts in the hilus on dendrites of interneurons. These studies provide the first step towards determining the functional interactions of the various cell types in the fascia dentata.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 693-707 |
| Number of pages | 15 |
| Journal | Neuroscience |
| Volume | 37 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1990 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
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Synaptic connections of dentate granule cells and hilar neurons : Results of paired intracellular recordings and intracellular horseradish peroxidase injections. / Scharfman, H. E.; Kunkel, D. D.; Schwartzkroin, Philip A.
In: Neuroscience, Vol. 37, No. 3, 1990, p. 693-707.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synaptic connections of dentate granule cells and hilar neurons
T2 - Results of paired intracellular recordings and intracellular horseradish peroxidase injections
AU - Scharfman, H. E.
AU - Kunkel, D. D.
AU - Schwartzkroin, Philip A
PY - 1990
Y1 - 1990
N2 - Simultaneous intracellular recordings were made in the dentate gyrus of rat hippocampal slices, from pairs of the following cell types: granule cells, interneurons located in the granule cell layer, hilar interneurons, and spiny hilar "mossy cells". Granule cells were found to have strong excitatory effects on mossy cells and interneurons. Interneurons inhibited granule cells as well as other interneurons. No synaptic connections from mossy cells onto other cell types were found, within the confines of the slice, using intracellular recording methods. However, at the ultrastructural level, axon terminals of horseradish peroxidase-filled mossy cells were found making synaptic contacts in the hilus on dendrites of interneurons. These studies provide the first step towards determining the functional interactions of the various cell types in the fascia dentata.
AB - Simultaneous intracellular recordings were made in the dentate gyrus of rat hippocampal slices, from pairs of the following cell types: granule cells, interneurons located in the granule cell layer, hilar interneurons, and spiny hilar "mossy cells". Granule cells were found to have strong excitatory effects on mossy cells and interneurons. Interneurons inhibited granule cells as well as other interneurons. No synaptic connections from mossy cells onto other cell types were found, within the confines of the slice, using intracellular recording methods. However, at the ultrastructural level, axon terminals of horseradish peroxidase-filled mossy cells were found making synaptic contacts in the hilus on dendrites of interneurons. These studies provide the first step towards determining the functional interactions of the various cell types in the fascia dentata.
UR - http://www.scopus.com/inward/record.url?scp=0024996186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024996186&partnerID=8YFLogxK
U2 - 10.1016/0306-4522(90)90100-I
DO - 10.1016/0306-4522(90)90100-I
M3 - Article
C2 - 2247219
AN - SCOPUS:0024996186
VL - 37
SP - 693
EP - 707
JO - Neuroscience
JF - Neuroscience
SN - 0306-4522
IS - 3
ER -