Symptoms of upper gastrointestinal dysfunction in Duchenne muscular dystrophy: Case-control study

K. M. Jaffe, Craig M McDonald, E. Ingman, J. Haas

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


A case-control study was undertaken to see if symptoms of upper gastrointestinal (UGI) (orophyaryngeal, esophageal, and gastric) dysfunction occurred more frequently in males afflicted with Duchenne muscular dystrophy (DMD) than healthy controls. Subjects included 55 children with confirmed DMD and 55 age-matched controls without neuromuscular disease. All subjects and/or their parents responded to a standard set of questions concerning the frequency of symptoms of UGI dysfunction. Responses of the DMD and control groups were compared using the Wilcoxon signed rank test. A significantly higher percentage of DMD patients experienced nasal quality to the voice, dysphagia, choking while eating, the need to clear the throat during or after eating, heartburn, and vomiting during or after meals, than did controls. Only one symptom-heartburn-was found significantly more frequently in the 33 nonambulatory than the 22 ambulatory DMD subjects. These findings document that feeding difficulty and symptoms consistent with oropharyngeal, esophageal, and gastric dysfunction are more frequent in the DMD population than healthy, age-matched controls.

Original languageEnglish (US)
Pages (from-to)742-744
Number of pages3
JournalArchives of Physical Medicine and Rehabilitation
Issue number10
StatePublished - 1990
Externally publishedYes


  • Gastrointestinal system
  • Muscular dystrophy

ASJC Scopus subject areas

  • Rehabilitation


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