Symptoms of schizotypal personality disorder in fragile X women

W. E. Sobesky, C. E. Hull, Randi J Hagerman

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Objective: The frequency of DSM III-R symptoms of schizotypal personality disorder as it relates to CGG amplification and to the cytogenetic expression of fragile X syndrome was explored. Method: Four groups of women were examined: 30 control mothers of children with developmental problems, 17 control women who grew up in fragile X families, 28 women cytogenetically negative but DNA positive for fragile X with a premutation, and 31 women who were DNA positive with an expanded mutation, most of whom were cytogenetically positive. All women were assessed using the Structured Interview for Schizotypy. Results: Eight of the nine women who received the DSM III-R schizotypal personality disorder diagnosis came from the two fragile X groups: four from the premutation group and four from the expanded mutation group. Twenty percent of fragile X carriers who received the gene from their mother, but none who received the gene from their father demonstrated schizotypal personality disorder. Conclusions: Women who carry the premutation and women with the full mutation may both show schizotypal features, although less commonly than previously reported.

Original languageEnglish (US)
Pages (from-to)247-255
Number of pages9
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Issue number2
StatePublished - 1994
Externally publishedYes


  • emotional problems
  • FMR-1
  • fragile X
  • schizotypal personality disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental and Educational Psychology


Dive into the research topics of 'Symptoms of schizotypal personality disorder in fragile X women'. Together they form a unique fingerprint.

Cite this