Abstract
Objective: The frequency of DSM III-R symptoms of schizotypal personality disorder as it relates to CGG amplification and to the cytogenetic expression of fragile X syndrome was explored. Method: Four groups of women were examined: 30 control mothers of children with developmental problems, 17 control women who grew up in fragile X families, 28 women cytogenetically negative but DNA positive for fragile X with a premutation, and 31 women who were DNA positive with an expanded mutation, most of whom were cytogenetically positive. All women were assessed using the Structured Interview for Schizotypy. Results: Eight of the nine women who received the DSM III-R schizotypal personality disorder diagnosis came from the two fragile X groups: four from the premutation group and four from the expanded mutation group. Twenty percent of fragile X carriers who received the gene from their mother, but none who received the gene from their father demonstrated schizotypal personality disorder. Conclusions: Women who carry the premutation and women with the full mutation may both show schizotypal features, although less commonly than previously reported.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 247-255 |
| Number of pages | 9 |
| Journal | Journal of the American Academy of Child and Adolescent Psychiatry |
| Volume | 33 |
| Issue number | 2 |
| State | Published - 1994 |
| Externally published | Yes |
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Keywords
- emotional problems
- FMR-1
- fragile X
- schizotypal personality disorder
ASJC Scopus subject areas
- Psychiatry and Mental health
- Developmental and Educational Psychology
Cite this
Symptoms of schizotypal personality disorder in fragile X women. / Sobesky, W. E.; Hull, C. E.; Hagerman, Randi J.
In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 33, No. 2, 1994, p. 247-255.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Symptoms of schizotypal personality disorder in fragile X women
AU - Sobesky, W. E.
AU - Hull, C. E.
AU - Hagerman, Randi J
PY - 1994
Y1 - 1994
N2 - Objective: The frequency of DSM III-R symptoms of schizotypal personality disorder as it relates to CGG amplification and to the cytogenetic expression of fragile X syndrome was explored. Method: Four groups of women were examined: 30 control mothers of children with developmental problems, 17 control women who grew up in fragile X families, 28 women cytogenetically negative but DNA positive for fragile X with a premutation, and 31 women who were DNA positive with an expanded mutation, most of whom were cytogenetically positive. All women were assessed using the Structured Interview for Schizotypy. Results: Eight of the nine women who received the DSM III-R schizotypal personality disorder diagnosis came from the two fragile X groups: four from the premutation group and four from the expanded mutation group. Twenty percent of fragile X carriers who received the gene from their mother, but none who received the gene from their father demonstrated schizotypal personality disorder. Conclusions: Women who carry the premutation and women with the full mutation may both show schizotypal features, although less commonly than previously reported.
AB - Objective: The frequency of DSM III-R symptoms of schizotypal personality disorder as it relates to CGG amplification and to the cytogenetic expression of fragile X syndrome was explored. Method: Four groups of women were examined: 30 control mothers of children with developmental problems, 17 control women who grew up in fragile X families, 28 women cytogenetically negative but DNA positive for fragile X with a premutation, and 31 women who were DNA positive with an expanded mutation, most of whom were cytogenetically positive. All women were assessed using the Structured Interview for Schizotypy. Results: Eight of the nine women who received the DSM III-R schizotypal personality disorder diagnosis came from the two fragile X groups: four from the premutation group and four from the expanded mutation group. Twenty percent of fragile X carriers who received the gene from their mother, but none who received the gene from their father demonstrated schizotypal personality disorder. Conclusions: Women who carry the premutation and women with the full mutation may both show schizotypal features, although less commonly than previously reported.
KW - emotional problems
KW - FMR-1
KW - fragile X
KW - schizotypal personality disorder
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UR - http://www.scopus.com/inward/citedby.url?scp=0028082452&partnerID=8YFLogxK
M3 - Article
C2 - 8150797
AN - SCOPUS:0028082452
VL - 33
SP - 247
EP - 255
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
SN - 0890-8567
IS - 2
ER -