Symptoms of Autism in Males with Fragile X Syndrome: A Comparison to Nonsyndromic ASD Using Current ADI-R Scores

Andrea McDuffie, Angela John Thurman, Randi J Hagerman, Leonard J Abbeduto

Research output: Contribution to journalArticle

33 Scopus citations


Symptoms of autism are frequent in males with fragile X syndrome (FXS), but it is not clear whether symptom profiles differ from those of nonsyndromic ASD. Using individual item scores from the Autism Diagnostic Inventory-Revised, we examined which current symptoms of autism differed in boys with FXS relative to same-aged boys diagnosed with nonsyndromic ASD. In addition, different subsamples of participants were matched on autism diagnostic status and severity of autism symptoms. Between-group comparisons revealed that boys with FXS showed significantly less impairment in Social Smiling than did age-, diagnostic-, and severity-matched boys with nonsyndromic ASD. Severity-matched boys with FXS showed more impairment in complex mannerisms than did boys with nonsyndromic ASD. Behavioral differences between FXS and nonsyndromic ASD may be of theoretical importance in understanding the causes and correlates of ASD in FXS and in developing and implementing appropriate treatments.

Original languageEnglish (US)
Pages (from-to)1925-1937
Number of pages13
JournalJournal of Autism and Developmental Disorders
Issue number7
StatePublished - Jan 11 2014



  • ADI-R
  • Autism spectrum disorder
  • Fragile X syndrome

ASJC Scopus subject areas

  • Developmental and Educational Psychology

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