Symptomatic pancreatic polypeptide-secreting tumor of the distal pancreas (PPoma)

Melinda Mortenson, Richard J Bold

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Our report describes a 46-yr-old woman who presented with watery diarrhea in the presence of multiple endocrine neoplasia type I (MEN I) syndrome. Of various potential pancreatic endocrine hormones, only serum levels of pancreatic polypeptide were elevated. Radiologic imaging failed to identify a pancreatic tumor; her diarrhea was therefore managed with subcutaneous administration of somatostatin. Three years later she developed gallstone pancreatitis with the subsequent development of a pancreatic pseudocyst. At exploration for drainage of the pseudocyst, intraoperative ultrasound identified a 6-mm tumor in the distal pancreas that was resected. Final pathology documented a pancreatic endocrine tumor with immunohistochemical staining demonstrating the presence of pancreatic polypeptide. The present case illustrates the symptomatology that may be associated with pancreatic polypeptide-secreting endocrine tumors of the pancreas.

Original languageEnglish (US)
Pages (from-to)153-156
Number of pages4
JournalInternational Journal of Gastrointestinal Cancer
Volume32
Issue number2-3
StatePublished - 2002

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Keywords

  • Endocrine tumor
  • Multiple endocrine neoplasia
  • Pancreas
  • Pancreatic polypeptide

ASJC Scopus subject areas

  • Gastroenterology
  • Endocrinology
  • Oncology

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