Symbiosis of biotechnology and biomaterials: Applications in tissue engineering of bone and cartilage

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

The three ingredients for the successful tissue engineering of bone and cartilage are regulatory signals, cells, and extracellular matrix. Recent advances in cellular and molecular biology of the growth and differentiation factors have set the stage for a symbiosis of biotechnology and biomaterials. Recent advances permit one to enunciate the rules of architecture for tissue engineering of bone and cartilage. The purification and cloning of bone morphogenetic proteins (BMPs) and growth factors such as platelet derived growth factors (PDCF), transforming growth factor-β (TCF-β), and insulin-like growth factors (IGF-I) will allow the design of an optimal combination of signals to initiate and promote development of skeletal stem cells into cartilage and bone. Successful and optimal bone and cartilage formation is a synergy of inductive and conductive strategies governed by biomechanics, optimal load bearing, and motion. BMPs function as inductive signals. Biomaterials (both natural and synthetic) mimic the extracellular matrix and play a role in conduction of bone and cartilage. Examples of biomaterials include hydroxyapatite, polyanhydrides, polyphosphoesters, polylactic acid, and polyglycolic acid. The prospects for novel biomaterials are immense, and they likely will be a fertile growth industry. Cooperative ventures between academia and industry and technology transfer from the federal government augur well for an exciting future for clinical applications.

Original languageEnglish (US)
Pages (from-to)192-195
Number of pages4
JournalJournal of Cellular Biochemistry
Volume56
Issue number2
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Symbiosis
Cartilage
Biocompatible Materials
Tissue Engineering
Biotechnology
Tissue engineering
Bone
Bone and Bones
Bone Morphogenetic Proteins
Insulin-Like Growth Factor I
Extracellular Matrix
Polyanhydrides
Industry
Bearings (structural)
Growth Differentiation Factors
Cytology
Bone Conduction
Polyglycolic Acid
Technology Transfer
Federal Government

Keywords

  • BMPS
  • Bone
  • Cartilage
  • PDGF
  • TGF-β

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

@article{57144f6a5bd34c038bce8de4ffb07264,
title = "Symbiosis of biotechnology and biomaterials: Applications in tissue engineering of bone and cartilage",
abstract = "The three ingredients for the successful tissue engineering of bone and cartilage are regulatory signals, cells, and extracellular matrix. Recent advances in cellular and molecular biology of the growth and differentiation factors have set the stage for a symbiosis of biotechnology and biomaterials. Recent advances permit one to enunciate the rules of architecture for tissue engineering of bone and cartilage. The purification and cloning of bone morphogenetic proteins (BMPs) and growth factors such as platelet derived growth factors (PDCF), transforming growth factor-β (TCF-β), and insulin-like growth factors (IGF-I) will allow the design of an optimal combination of signals to initiate and promote development of skeletal stem cells into cartilage and bone. Successful and optimal bone and cartilage formation is a synergy of inductive and conductive strategies governed by biomechanics, optimal load bearing, and motion. BMPs function as inductive signals. Biomaterials (both natural and synthetic) mimic the extracellular matrix and play a role in conduction of bone and cartilage. Examples of biomaterials include hydroxyapatite, polyanhydrides, polyphosphoesters, polylactic acid, and polyglycolic acid. The prospects for novel biomaterials are immense, and they likely will be a fertile growth industry. Cooperative ventures between academia and industry and technology transfer from the federal government augur well for an exciting future for clinical applications.",
keywords = "BMPS, Bone, Cartilage, PDGF, TGF-β",
author = "Reddi, {A Hari}",
year = "1994",
doi = "10.1002/jcb.240560213",
language = "English (US)",
volume = "56",
pages = "192--195",
journal = "Journal of Cellular Biochemistry",
issn = "0730-2312",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Symbiosis of biotechnology and biomaterials

T2 - Applications in tissue engineering of bone and cartilage

AU - Reddi, A Hari

PY - 1994

Y1 - 1994

N2 - The three ingredients for the successful tissue engineering of bone and cartilage are regulatory signals, cells, and extracellular matrix. Recent advances in cellular and molecular biology of the growth and differentiation factors have set the stage for a symbiosis of biotechnology and biomaterials. Recent advances permit one to enunciate the rules of architecture for tissue engineering of bone and cartilage. The purification and cloning of bone morphogenetic proteins (BMPs) and growth factors such as platelet derived growth factors (PDCF), transforming growth factor-β (TCF-β), and insulin-like growth factors (IGF-I) will allow the design of an optimal combination of signals to initiate and promote development of skeletal stem cells into cartilage and bone. Successful and optimal bone and cartilage formation is a synergy of inductive and conductive strategies governed by biomechanics, optimal load bearing, and motion. BMPs function as inductive signals. Biomaterials (both natural and synthetic) mimic the extracellular matrix and play a role in conduction of bone and cartilage. Examples of biomaterials include hydroxyapatite, polyanhydrides, polyphosphoesters, polylactic acid, and polyglycolic acid. The prospects for novel biomaterials are immense, and they likely will be a fertile growth industry. Cooperative ventures between academia and industry and technology transfer from the federal government augur well for an exciting future for clinical applications.

AB - The three ingredients for the successful tissue engineering of bone and cartilage are regulatory signals, cells, and extracellular matrix. Recent advances in cellular and molecular biology of the growth and differentiation factors have set the stage for a symbiosis of biotechnology and biomaterials. Recent advances permit one to enunciate the rules of architecture for tissue engineering of bone and cartilage. The purification and cloning of bone morphogenetic proteins (BMPs) and growth factors such as platelet derived growth factors (PDCF), transforming growth factor-β (TCF-β), and insulin-like growth factors (IGF-I) will allow the design of an optimal combination of signals to initiate and promote development of skeletal stem cells into cartilage and bone. Successful and optimal bone and cartilage formation is a synergy of inductive and conductive strategies governed by biomechanics, optimal load bearing, and motion. BMPs function as inductive signals. Biomaterials (both natural and synthetic) mimic the extracellular matrix and play a role in conduction of bone and cartilage. Examples of biomaterials include hydroxyapatite, polyanhydrides, polyphosphoesters, polylactic acid, and polyglycolic acid. The prospects for novel biomaterials are immense, and they likely will be a fertile growth industry. Cooperative ventures between academia and industry and technology transfer from the federal government augur well for an exciting future for clinical applications.

KW - BMPS

KW - Bone

KW - Cartilage

KW - PDGF

KW - TGF-β

UR - http://www.scopus.com/inward/record.url?scp=0028032811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028032811&partnerID=8YFLogxK

U2 - 10.1002/jcb.240560213

DO - 10.1002/jcb.240560213

M3 - Article

C2 - 7829580

AN - SCOPUS:0028032811

VL - 56

SP - 192

EP - 195

JO - Journal of Cellular Biochemistry

JF - Journal of Cellular Biochemistry

SN - 0730-2312

IS - 2

ER -