Sweet's syndrome-like neutrophilic lobular panniculitis associated with all-trans-retinoic acid chemotherapy in a patient with acute promyelocytic leukemia

Jared Jagdeo, Ross Campbell, Thomas Long, Jennie Muglia, Gladys Telang, Leslie Robinson-Bostom

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Sweet's syndrome-like (Sweet's-like) neutrophilic panniculitis is usually idiopathic, but is frequently associated with hematologic, inflammatory, and immunologic disease. Drug-related cases of Sweet's syndrome have been reported. Of relevance, chemotherapy with the retinoid all-trans-retinoic acid (ATRA) infrequently induces Sweet's-like neutrophilic panniculitis that occurs concomitantly with neutrophilic differentiation. The pathologic features are limited to the adipose tissue or include both the dermis and the subcutaneous fat; the neutrophilic infiltrate can be observed in the lobules, the septae, or both. We present this case because of the unusual subcutaneous neutrophilic infiltrate consistent with Sweet's-like neutrophilic lobular panniculitis in a patient with acute promyelocytic leukemia receiving ATRA chemotherapy. This case highlights the important connection between ATRA and Sweet's syndrome.

Original languageEnglish (US)
Pages (from-to)690-693
Number of pages4
JournalJournal of the American Academy of Dermatology
Volume56
Issue number4
DOIs
StatePublished - Apr 2007
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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