Susceptibilities of simian immunodeficiency virus to protease inhibitors

Angelica C. Giuffre, Joanne Higgins, Robert W. Buckheit, Thomas W. North

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


We used a focal infectivity assay with HeLa H1-JC.37 cells to directly compare susceptibilities of simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) to protease inhibitors. SIVmac239 was inhibited by indinavir, saquinavir, and ritonavir, with 50% effective concentrations (means ± standard deviations) of 39 ± 8, 55 ± 3, and 13 ± 5 nM, respectively. The corresponding values for inhibition of HIV-1 were 66 ± 4, 47 ± 10, and 25 ± 14 nM, respectively.

Original languageEnglish (US)
Pages (from-to)1756-1759
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Issue number5
StatePublished - May 1 2003

ASJC Scopus subject areas

  • Pharmacology (medical)


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