Susceptibilities of simian immunodeficiency virus to protease inhibitors

Angelica C. Giuffre, Joanne Higgins, Robert W. Buckheit, Thomas W. North

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

We used a focal infectivity assay with HeLa H1-JC.37 cells to directly compare susceptibilities of simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) to protease inhibitors. SIVmac239 was inhibited by indinavir, saquinavir, and ritonavir, with 50% effective concentrations (means ± standard deviations) of 39 ± 8, 55 ± 3, and 13 ± 5 nM, respectively. The corresponding values for inhibition of HIV-1 were 66 ± 4, 47 ± 10, and 25 ± 14 nM, respectively.

Original languageEnglish (US)
Pages (from-to)1756-1759
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume47
Issue number5
DOIs
StatePublished - May 1 2003

ASJC Scopus subject areas

  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Susceptibilities of simian immunodeficiency virus to protease inhibitors'. Together they form a unique fingerprint.

  • Cite this