Susceptibilities of simian immunodeficiency virus to protease inhibitors

Angelica C. Giuffre, Joanne Higgins, Robert W. Buckheit, Thomas W. North

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We used a focal infectivity assay with HeLa H1-JC.37 cells to directly compare susceptibilities of simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) to protease inhibitors. SIVmac239 was inhibited by indinavir, saquinavir, and ritonavir, with 50% effective concentrations (means ± standard deviations) of 39 ± 8, 55 ± 3, and 13 ± 5 nM, respectively. The corresponding values for inhibition of HIV-1 were 66 ± 4, 47 ± 10, and 25 ± 14 nM, respectively.

Original languageEnglish (US)
Pages (from-to)1756-1759
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume47
Issue number5
DOIs
StatePublished - May 1 2003

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Simian Immunodeficiency Virus
Protease Inhibitors
HIV-1
Saquinavir
Indinavir
Ritonavir

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Susceptibilities of simian immunodeficiency virus to protease inhibitors. / Giuffre, Angelica C.; Higgins, Joanne; Buckheit, Robert W.; North, Thomas W.

In: Antimicrobial Agents and Chemotherapy, Vol. 47, No. 5, 01.05.2003, p. 1756-1759.

Research output: Contribution to journalArticle

Giuffre, Angelica C. ; Higgins, Joanne ; Buckheit, Robert W. ; North, Thomas W. / Susceptibilities of simian immunodeficiency virus to protease inhibitors. In: Antimicrobial Agents and Chemotherapy. 2003 ; Vol. 47, No. 5. pp. 1756-1759.
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