Survival times in dogs with right atrial hemangiosarcoma treated by means of surgical resection with or without adjuvant chemotherapy

23 Cases (1986-2000)

Chick Weisse, Nancy Soares, Matthew W. Beal, Michele A Steffey, Kenneth J. Drobatz, Carolyn J. Henry

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Objective - To determine survival times in dogs with right atrial hemangiosarcoma treated by means of pericardectomy and tumor resection, with or without adjuvant chemotherapy, and identify complications associated with treatment. Design - Retrospective study. Animals - 23 dogs. Procedure - Dogs were included only if the diagnosis was confirmed histologically. Results - The most common initial complaints included acute collapse (8 [35%] dogs), anorexia or inappetence (8 [35%]), and lethargy (8 [35%]).The most common physical examination abnormalities included muffled heart sounds (12 [52%] dogs), tachycardia (7 [30%])•, and weak pulses (7 [30%]). Postoperative complications developed in 12 (52%) dogs; however, most complications were minor. Twenty (87%) dogs were discharged from the hospital. Survival time was significantly longer in the 8 dogs that received adjuvant chemotherapy (mean, 164 days; median, 175 days) than in the 15 dogs that did not receive chemotherapy (mean, 46 days; median, 42 days). Dogs that received chemotherapy were significantly younger and had significantly lower WBC counts than did dogs that did not receive chemotherapy. Conclusions and Clinical Relevance - Results suggested that in dogs with right atrial hemangiosarcoma, surgical resection of the tumor was associated with a low complication rate and complications that did arise typically were minor. In addition, use of adjuvant chemotherapy following resection was associated with significantly longer survival times, compared with resection alone.

Original languageEnglish (US)
Pages (from-to)575-579
Number of pages5
JournalJournal of the American Veterinary Medical Association
Volume226
Issue number4
DOIs
StatePublished - Feb 15 2005
Externally publishedYes

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hemangiosarcoma
Hemangiosarcoma
resection
Adjuvant Chemotherapy
drug therapy
adjuvants
Dogs
dogs
Drug Therapy
heart sounds
Pericardiectomy
Heart Sounds
Lethargy
neoplasms
postoperative complications
Anorexia
anorexia
leukocyte count
retrospective studies
Tachycardia

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Survival times in dogs with right atrial hemangiosarcoma treated by means of surgical resection with or without adjuvant chemotherapy : 23 Cases (1986-2000). / Weisse, Chick; Soares, Nancy; Beal, Matthew W.; Steffey, Michele A; Drobatz, Kenneth J.; Henry, Carolyn J.

In: Journal of the American Veterinary Medical Association, Vol. 226, No. 4, 15.02.2005, p. 575-579.

Research output: Contribution to journalArticle

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abstract = "Objective - To determine survival times in dogs with right atrial hemangiosarcoma treated by means of pericardectomy and tumor resection, with or without adjuvant chemotherapy, and identify complications associated with treatment. Design - Retrospective study. Animals - 23 dogs. Procedure - Dogs were included only if the diagnosis was confirmed histologically. Results - The most common initial complaints included acute collapse (8 [35{\%}] dogs), anorexia or inappetence (8 [35{\%}]), and lethargy (8 [35{\%}]).The most common physical examination abnormalities included muffled heart sounds (12 [52{\%}] dogs), tachycardia (7 [30{\%}])•, and weak pulses (7 [30{\%}]). Postoperative complications developed in 12 (52{\%}) dogs; however, most complications were minor. Twenty (87{\%}) dogs were discharged from the hospital. Survival time was significantly longer in the 8 dogs that received adjuvant chemotherapy (mean, 164 days; median, 175 days) than in the 15 dogs that did not receive chemotherapy (mean, 46 days; median, 42 days). Dogs that received chemotherapy were significantly younger and had significantly lower WBC counts than did dogs that did not receive chemotherapy. Conclusions and Clinical Relevance - Results suggested that in dogs with right atrial hemangiosarcoma, surgical resection of the tumor was associated with a low complication rate and complications that did arise typically were minor. In addition, use of adjuvant chemotherapy following resection was associated with significantly longer survival times, compared with resection alone.",
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